Severity: Warning
Message: fopen(/var/lib/php/sessions/ci_sessionn57ve0kbucm2o1gstha6irgh4qmra40j): Failed to open stream: No space left on device
Filename: drivers/Session_files_driver.php
Line Number: 177
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: Warning
Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)
Filename: Session/Session.php
Line Number: 137
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 197
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 197
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 271
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1057
Function: getPubMedXML
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3175
Function: GetPubMedArticleOutput_2016
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
A novel phosphorescent probe based on ion-paired iridium(III) complex has been designed and synthesized by incorporating α,β-unsaturated ketone moiety in the cationic component. The phosphorescent intensity of cationic component is sensitive to bithiols, such as cysteine and homocysteine, based on the addition reaction of bithiols with α,β-unsaturated ketone moiety, while that of the anionic component remains unchanged. Thus, this ion-paired iridium(III) complex can be used for ratiometric luminescence sensing and imaging of intracellular biothiols with excellent sensing performance. Moreover, the long phosphorescence lifetime of the cationic component is also sensitive to bithiols. Hence, this ion-paired iridium(III) complex has been further used for time-resolved luminescence imaging of intracellular biothiols. As far as we know, this is the first report about molecular probe for both ratiometric and time-resolved luminescence imaging of intracellular biothiols.
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Source |
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http://dx.doi.org/10.1364/OE.24.028247 | DOI Listing |
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