Characteristics and pharmacodynamics of severe neuroinflammation in a child with neurolupus.

Neurol Neuroimmunol Neuroinflamm

National Pediatric Neuroinflammation Organization, Inc. (M.R.P., N.R.M.), Orlando, FL; Department of Neurology, University of Louisville (Z.Y.W.), KY; and Department of Neurology, Santa Clara Valley Medical Center (B.K.A.), San Jose, CA.

Published: March 2017

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141525PMC
http://dx.doi.org/10.1212/NXI.0000000000000316DOI Listing

Publication Analysis

Top Keywords

characteristics pharmacodynamics
4
pharmacodynamics severe
4
severe neuroinflammation
4
neuroinflammation child
4
child neurolupus
4
characteristics
1
severe
1
neuroinflammation
1
child
1
neurolupus
1

Similar Publications

Construction of a Novel Necroptosis-Related Signature in Rat DRG for Neuropathic Pain.

J Inflamm Res

January 2025

Department of Pharmacology, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of New Drug Pharmacology and Toxicology, Center of Innovative Drug Research and Evaluation, Hebei Medical University, Shijiazhuang, People's Republic of China.

Background: Recent studies have shown necroptosis may play a role in the development of inflammation-associated pain. However, research on the correlation between necroptosis-related genes and neuropathic pain in the dorsal root ganglia (DRG) is limited. This study aims to identify a gene signature related to necroptosis in DRG that can predict neuropathic pain.

View Article and Find Full Text PDF

The delivery of molecules, such as DNA, RNA, peptides, and certain hydrophilic drugs, across the epidermal barrier poses a significant obstacle. Microneedle technology has emerged as a prominent area of focus in biomedical research because of its ability to deliver a wide range of biomolecules, vaccines, medicines, and other substances through the skin. Microneedles (MNs) form microchannels by disrupting the skin's structure, which compromises its barrier function, and facilitating the easy penetration of drugs into the skin.

View Article and Find Full Text PDF

Brainprint recognition technology, regarded as a promising biometric technology, encounters challenges stemming from the time-varied, low signal-to-noise ratio of brain signals, such as electroencephalogram (EEG). Steady-state visual evoked potentials (SSVEP) exhibit high signal-to-noise ratio and frequency locking, making them a promising paradigm for brainprint recognition. Consequently, the extraction of time-invariant identity information from SSVEP EEG signals is essential.

View Article and Find Full Text PDF

Analyzing collaborations in clinical trials in Korea using association rule mining.

Transl Clin Pharmacol

December 2024

Department of Pharmaceutical Science and Technology, Kyungsung University, Busan 48434, Korea.

Identifying how trial sites collaborate is essential for multicenter trials. The ways in which collaboration among trial sites is established can vary according to study phase and clinical trial domains. In this study, we employed association rule mining to reveal trial collaboration.

View Article and Find Full Text PDF

Pathogen-associated molecular patterns (PAMPs) are highly conserved motifs originating from microorganisms that act as ligands for pattern recognition receptors (PRRs), which are crucial for defense against pathogens. Thus, PAMP-mimicking vaccines may induce potent immune activation and provide broad-spectrum protection against microbes. Dextran encapsulation can regulate the surface characteristics of nanoparticles (NPs) and induces their surface modification.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!