AI Article Synopsis
- TLR (Toll-like receptor) 10 suppresses B cell activities such as proliferation and cytokine production when activated, contrasting with other TLRs known to stimulate B cell responses.
- When TLR10 transgenic mice encounter antigens, they show reduced antibody responses, indicating the receptor's inhibitory effect on the immune response.
- These findings highlight TLR10's unique role within B cells and suggest it could be a therapeutic target for conditions where B cell function is abnormal.
Article Abstract
Toll-like receptors play a central role in the initiation of adaptive immune responses with several TLR agonists acting as known B cell mitogens. Despite thousands of publications on TLRs, the function of TLR10 remains unknown. We have found that Ab-mediated engagement of TLR10 on primary human B cells suppresses B cell proliferation, cytokine production, and signal transduction. When challenged with either a T independent or T dependent Ag, TLR10 transgenic mice exhibit diminished Ab responses. Adoptive transfer of splenic B cells into B cell-deficient mice revealed that the suppressive effects on Ag-specific humoral immune responses are entirely B cell intrinsic. Our results demonstrate that TLR10 has a functional role within the B cell lineage that is distinct from that of other TLR family members and may provide a potential therapeutic target for diseases characterized by dysregulated B cell activity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225023 | PMC |
| http://dx.doi.org/10.4049/jimmunol.1601335 | DOI Listing |
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