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Gastrointestinal stromal tumors or GISTs are the most common mesenchymal tumors of the gastrointestinal tract; only a few cases have been reported at other sites. The prognosis of GISTs depends on their size and mitotic rate. Surgical removal is the treatment of choice although imatinib shows clinical benefits.
View Article and Find Full Text PDFCase report: Characterization and bioinformatics analysis of non-O1/O139 strain isolated from a choledochoduodenal fistula patient with septicemia.
Front Med (Lausanne)
October 2024
Department of Infectious Diseases, People's Hospital of Xiushan County, Xiushan, China.
The gram-negative bacterium (VC) is divided into multiple serogroups, with groups O1 and O139 responsible for cholera. Conversely, belonging to the non-O1/non-O139 group (NOVC) does not produce cholera-causing toxins. Insufficient understanding of the frequency of NOVC causes fear during the early detection phase.
View Article and Find Full Text PDFIsolated liver gastrointestinal stromal tumor: A case report.
J Clin Ultrasound
October 2024
Department of Ultrasound in Medicine, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China.
Article Synopsis
- A case study detailed a 38-year-old man with multiple cystic-solid liver lesions, ultimately diagnosed as a liver GIST after a CT-guided biopsy, but distinguishing between PLGIST and LMGIST was complicated due to missing medical history.
- The study emphasizes the importance of understanding this rare liver tumor type for better diagnosis and staging, especially as the lesions increased in size during a two-year follow-up without any other lesions found outside the liver.
Rare Double Primary Malignancies: A Pancreatic Gastrointestinal Stromal Tumor Mimicking as a Metastatic Lesion of Myoepithelial Carcinoma of Parotid Gland.
Case Rep Med
December 2023
Staff of Digestive Division of General Surgery Department, Faculty of Medicine, Universitas Indonesia, General Surgery Department, Cipto Mangunkusumo Hospital, Diponegoro Street #71, Senen, Central Jakarta, Indonesia.
Pancreatic gastrointestinal stromal tumors (PGISTs) are exceptionally rare, accounting for <5% of extra-gastrointestinal stromal tumors (EGISTs) and <1% of malignant pancreatic neoplasms. We present a unique case of concurrent double primary malignancies in a 46-year-old female with a history of recurrent myoepithelial carcinoma of the parotid gland, managed through surgical resection and adjuvant therapy. She presented with an enlarging abdominal mass, initially suggestive of pancreatic metastasis.
View Article and Find Full Text PDFGlutamine Supplementation as a Novel Metabolic Therapeutic Strategy for LIG3-Dependent Chronic Intestinal Pseudo-Obstruction.
Gastroenterology
January 2025
Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy; Istituto di Ricovero e Cura a Carattere Scientifico, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Article Synopsis
- Researchers discovered a recessive syndrome linked to mutations in the DNA ligase 3 (LIG3) gene that causes chronic intestinal pseudo-obstruction and other neurological issues due to impaired mitochondrial DNA maintenance and energy production.
- They performed whole transcriptome analysis on patient fibroblasts, finding deregulated genes related to mitochondrial function and extracellular matrix development, and tested l-glutamine supplementation to address energy impairments.
- Treatment with l-glutamine significantly improved the symptoms of patients with LIG3 mutations, highlighting its potential as a targeted therapy for mitochondrial dysfunction related to this condition.*
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