Tritrichomonas foetus infects the bovine urogenital tract, causing bovine trichomoniasis. Significant economic losses may occur due to infertility and abortion among cattle. Trichomonas vaginalis is the causative agent of trichomoniasis; the most common but overlooked non-viral sexually transmitted disease worldwide. Human and bovine trichomoniasis present treatment restrictions and efforts to identify new alternatives are essential. The present study evaluated the anti-trichomonads activities of seven fractions from northwest endemic plant Manilkara rufula. Flavonoids and condensed tannins were identified from these fractions by LC-DAD-MS/MS and MALDI-MS/MS. Altogether, the results demonstrated for the first time the structural description of tannins from leaves of M. rufula and the relation of these compounds with anti-T. vaginalis and anti-T. foetus activities. Overall, this report reveals the potential of M. rufula fractions against both parasites and shows new alternatives to treat the infection caused by trichomonads.
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| http://dx.doi.org/10.1016/j.exppara.2016.12.006 | DOI Listing |
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Article Synopsis
- Trichomonas vaginalis is the cause of trichomoniasis, a common but often overlooked sexually transmitted infection, and resistance to treatment is an issue.
- Various plants from the unique Brazilian Caatinga biome were investigated for their potential to combat T. vaginalis, leading to the identification of several bioactive compounds in Manilkara rufula.
- One compound, ursolic acid, significantly reduced parasite viability and showed potential as a co-treatment with metronidazole against resistant strains.
Screening of Caatinga plants as sources of lectins and trypsin inhibitors.
Nat Prod Res
November 2014
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Although it is one of the most threatened areas in the Earth, there are few studies on the biotechnological potential of the Caatinga. This work evaluated 36 extracts from 27 Caatinga plants for lectin and trypsin inhibitor activities. The presence of lectin was detected in 77.
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