Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357955 | PMC |
| http://dx.doi.org/10.1016/j.tibs.2016.11.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells.
Nat Commun
December 2024
Department of Medicine, Columbia Center for Human Development and Stem Cell Therapies, Columbia University Irving Medical Center, New York, NY, USA.
Pluripotent stem cells possess a unique nuclear architecture characterized by a larger nucleus and more open chromatin, which underpins their ability to self-renew and differentiate. Here, we show that the nucleolus-specific RNA helicase DDX18 is essential for maintaining the pluripotency of human embryonic stem cells. Using techniques such as Hi-C, DNA/RNA-FISH, and biomolecular condensate analysis, we demonstrate that DDX18 regulates nucleolus phase separation and nuclear organization by interacting with NPM1 in the granular nucleolar component, driven by specific nucleolar RNAs.
View Article and Find Full Text PDFPhase-transition-induced dynamic surface wrinkle pattern on gradient photo-crosslinking liquid crystal elastomer.
Nat Commun
December 2024
School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, China.
Liquid crystal elastomers (LCEs) with various deformation properties based on phase transition were widely used as actuators and provided potential to fabricate functional surfaces with tunable microstructure. Herein, we demonstrate a strategy to fabricate dynamic micro wrinkles on LCE surfaces based on LC phase transition. Stable micron-sized surface wrinkles on the anthracene-containing LCE film (AnLCE) are fabricated by ultraviolet exposure induced gradient cross-linking and subsequently stretching-releasing (UV-SR).
View Article and Find Full Text PDFSelf-assembly by anti-repellent structures for programming particles with momentum.
Nat Commun
December 2024
Department of Electronics and Information Convergence Engineering, Kyung Hee University, Yongin-si, Republic of Korea.
Self-assembled configurations are versatile for applications in which liquid-mediated phenomena are employed to ensure that static or mild physical interactions between assembling blocks take advantage of local energy minima. For granular materials, however, a particle's momentum in air leads to random collisions and the formation of disordered phases, eventually producing jammed configurations when densely packed. Therefore, unlike fluidic self-assembly, the self-assembly of dry particles typically lacks programmability based on density and ordering symmetry and has thus been limited in applications.
View Article and Find Full Text PDFAZR-MD-001 0.5% selenium sulfide ophthalmic ointment for the treatment of contact lens discomfort: A vehicle-controlled, randomized, clinical trial.
Ocul Surf
December 2024
AZURA Ophthalmics, Tel-Aviv, Israel.
Background: Contact lens discomfort (CLD) is a common problem for CL wearers, and patients with CLD often have changes in meibomian gland function and structure. In a Phase 2 trial AZR-MD-001 0.5% (AZR) ophthalmic ointment improved meibomian gland dysfunction (MGD) in non-lens wearers.
View Article and Find Full Text PDFAdvancing characterization of pyrolysis products: Comprehensive gas chromatography methods for analytes in gas and liquid phases.
J Chromatogr A
December 2024
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5. Electronic address:
The development of biofuel technologies depends on the accurate identification and quantification of products from the conversion processes. Given the complexity of the renewable resources, the availability of biomass, and the versatility of conversion methods, there is a need for characterization methods that provide rapid and reliable analysis for various products coming from different conversion processes with minimal sample preparation. This study develops and validates gas chromatography methods that use multiple detectors to analyze pyrolytic compounds in both gas and liquid phases efficiently in a single, rapid run.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!