We describe a 44-year-old man who developed akinetic mutism following a cerebrovascular accident involving his left middle cerebral artery. We discuss this rare condition and its unusual clinical picture.
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Clinical Manifestations.
Alzheimers Dement
December 2024
Neurological Institute of Thailand, Ratchathewi, Bangkok, Thailand.
Background: Sporadic Creutzfeldt-Jakob disease (sCJD) is one of common causes of rapidly progressive dementia worldwide. However, because of the variety of its clinical presentations that mimic other cognitive disorders, the certain diagnosis in public hospitals is still limited. Therefore, this study provides more information about disease manifestations and clinical courses of probable sCJD cases in Thailand.
View Article and Find Full Text PDFA predictive model for cerebellar mutism syndrome based on lesion map in children with medulloblastoma.
Eur Radiol
December 2024
Department of Neurosurgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Background: This study aimed to establish a voxel-based map to predict the occurrence of cerebellar mutism syndrome (CMS) and investigate the relationship between CMS and motor dysfunction.
Method: This multicenter study cohort included 224 patients diagnosed with medulloblastoma at Beijing Children's Hospital (n = 88) and Beijing Tiantan Hospital (n = 136). The dataset was randomly divided into training (n = 95), test (n = 41), and validation (n = 88) datasets.
Sporadic Creutzfeldt-Jakob Disease: A Rare Case of Rapid Progressive Cognitive Decline with Special Reference to Magnetic Resonance Spectroscopy.
J Assoc Physicians India
November 2024
Associate Professor, Department of General Medicine, Medical College Baroda, Vadodara, Gujarat, India.
Article Synopsis
- - Creutzfeldt-Jakob disease (CJD) is a rare and fatal brain disorder that typically affects people in their 60s and manifests as rapid cognitive decline due to the accumulation of abnormal prion proteins, leading to death within a year of diagnosis.
- - Diagnosis of CJD is complicated by overlapping symptoms with other degenerative and infectious diseases, requiring a comprehensive approach that includes clinical evaluations and advanced imaging techniques.
- - A case study of a 60-year-old man with probable sporadic CJD highlights symptoms such as dementia and rigidity, as well as MRI findings that indicate severe neurodegeneration, demonstrating the need for early identification for palliative care, since there is no effective treatment.
Intermittent Akinetic Mutism after Bilateral Paramedian Thalamic Infarction Caused by Artery of Percheron Occlusion:A Case Report.
J Med Invest
October 2024
Department of Neurosurgery, Tokyo Women's Medical University Adachi Medical Center, Tokyo, Japan.
Intermittent clinical course of akinetic mutism is very unusual. We describe a 74-year-old man who started to demonstrate episodes of altered mental state with stopped moving and talking, poor response to commands, and muscle stiffness in both upper limbs approximately 1.5 months after cardioembolic bilateral paramedian thalamic infarction.
View Article and Find Full Text PDFSporadic Creutzfeldt Jakob disease: Case series in Peru.
Colomb Med (Cali)
October 2024
Hospital Nacional Edgardo Rebagliati Martins, Departamento de Neurología, Lima, Peru.
Description Of The Cases: A series of 6 cases with a probable diagnosis of sporadic CJD, treated in a Peruvian national reference hospital, are presented.
Clinical Findings: The relevant clinical signs were rapidly progressive dementia and myoclonus, followed by akinetic mutism and pyramidal signs.
Treatment And Results: Of the cases presented, 80% were men, with an average age of presentation of 65 years and duration from diagnosis to death of 6.
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