AI Article Synopsis
- Platelets are involved in various key bodily functions like blood clotting, immune response, and even cancer development.
- Platelet-derived extracellular vesicles (PDEVs) are gaining attention as important mediators and potential biomarkers due to their numerous roles in these processes.
- The chapter discusses methods for isolating PDEVs from blood or activated platelets and clarifies that PDEVs refer to vesicles from both platelets and their precursor cells, megakaryocytes.
Article Abstract
Platelets participate in several physiological functions, including hemostasis, immunity, and development. Additionally, platelets play key roles in arterial thrombosis and cancer progression. Given this plethora of functions, there is a strong interest of the role of platelet-derived (extracellular) vesicles (PDEVs) as functional mediators and biomarkers. Moreover, the majority of the blood-borne EVs are thought to originate from either platelets or directly from the platelet precursor cells, the megakaryocytes, which reside in the bone marrow. To circumvent confusion, we use the term PDEVs for both platelet-derived and/or megakaryocyte-derived EVs. PDEVs can be isolated from blood or from isolated platelets after activation. In this chapter, we describe all commonly used PDEV isolation methods from blood and prepurified platelets.
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| http://dx.doi.org/10.1007/978-1-4939-6728-5_12 | DOI Listing |
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