Borrowing from the wafer-level fabrication techniques of the Utah Electrode Array, an optical array capable of delivering light for neural optogenetic studies is presented in this paper: the Utah Optrode Array. Utah Optrode Arrays are micromachined out of sheet soda-lime-silica glass using standard backend processes of the semiconductor and microelectronics packaging industries such as precision diamond grinding and wet etching. 9 × 9 arrays with 1100μ m × 100μ m optrodes and a 500μ m back-plane are repeatably reproduced on 2i n wafers 169 arrays at a time. This paper describes the steps and some of the common errors of optrode fabrication.
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optogenetics using a Utah Optrode Array with enhanced light output and spatial selectivity.
J Neural Eng
August 2024
Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT, United States of America.
Optogenetics allows the manipulation of neural circuitswith high spatial and temporal precision. However, combining this precision with control over a significant portion of the brain is technologically challenging (especially in larger animal models).Here, we have developed, optimised, and tested, the Utah Optrode Array (UOA), an electrically addressable array of optical needles and interstitial sites illuminated by 181LEDs and used to optogenetically stimulate the brain.
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Department of Ophthalmology and Visual Science, Moran Eye Institute, University of Utah, Salt Lake City, UT, USA.
Optogenetics has transformed studies of neural circuit function, but remains challenging to apply to non-human primates (NHPs). A major challenge is delivering intense, spatiotemporally-precise, patterned photostimulation across large volumes in deep tissue. Such stimulation is critical, for example, to modulate selectively deep-layer corticocortical feedback circuits.
View Article and Find Full Text PDFOptogenetics has transformed studies of neural circuit function, but remains challenging to apply in non-human primates (NHPs). A major challenge is delivering intense and spatially precise patterned photostimulation across large volumes in deep tissue. Here, we have developed and validated the Utah Optrode Array (UOA) to meet this critical need.
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