Prevalence of Multidrug-resistant, Extensively Drug-resistant, and Pandrug-resistant from a Tertiary Level Intensive Care Unit.

Background: Infection by is common in the Intensive Care Unit (ICU), leading to increased morbidity and mortality. The organism is classified into various phenotypes based on the drug resistance pattern, namely, drug-resistant (DR), multi-DR (MDR), extensively DR (XDR), and pan-DR (PDR). We aim to study the incidence of phenotypes in a tertiary level ICU.

Materials And Methods: We conducted this prospective, observational study for 2 years (January 2014-December 2015) and collected appropriate clinical samples (blood, urine, wound discharge, etc.,) from all the patients admitted to ICU. We excluded patients with known septicemia and infection. Group 1 comprised a total 1915 patient samples and Group 2 comprised 100 active surveillance samples, collected from the medical staff and the hospital environment. The data were analyzed using appropriate statistical methods, and a < 0.05 was considered statistically significant.

Results: We isolated 597 pathogenic bacteria out of 1915 specimens, giving a culture positivity rate of 31.2%. (43%), (22%), and (15%) were the top three isolated bacteria. None of the surveillance samples grew . Antibiotic resistance studies revealed that 47.7% of isolates were DR, 50% were MDR, and 2.3% were XDR phenotype. None of the strains showed PDR phenotype.

Conclusion: Our data revealed a high prevalence of DR phenotypes of in the ICU. Judicious use of antibiotics and strict infection control measures are essential to reduce the prevalence of drug resistance.