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Mertk signaling and immune regulation in T cells.
J Leukoc Biol
December 2024
Department of Microbiology, Biochemistry and Molecular Genetics, Center for Cell Signaling, Rutgers New Jersey Medical School, 205 South Orange Ave, Newark, NJ 07103, United States.
While widely viewed as inhibitory receptors that drive efferocytosis and immune resolution on myeloid cells, TAM family members, particularly Mertk, have emerged as promising targets in immune-oncology to help stimulate host antitumor immunity. A recent study shows that Mertk expressed on human T cells, including CD8+ T cells and differentiated central memory T cells, has a co-stimulatory function for the T Cell Receptor. These new findings reveal the complexity and diversification of Mertk in immune regulation and its implications to cancer therapeutics.
View Article and Find Full Text PDFMentorship of Junior Surgical Faculty Across Academic Programs in Surgery.
JAMA Surg
November 2024
Department of Surgery, University of California Irvine Medical Center, Orange.
Importance: Because mentorship is critical for professional development and career advancement, it is essential to examine the status of mentorship and identify challenges that junior surgical faculty (assistant and associate professors) face obtaining effective mentorship.
Objective: To evaluate the mentorship experience for junior surgical faculty and highlight areas for improvement.
Design, Setting, And Participants: This qualitative study was an explanatory sequential mixed-methods study including an anonymous survey on mentorship followed by semistructured interviews to expand on survey findings.
Reply to Editorial Comment on "Factors Affecting Implant Length in Primary Inflatable Penile Prosthesis Placement".
Urology
November 2024
Department of Surgery, Urology Section, Brooke Army Medical Center, San Antonio, TX.
Does PPG, the Other Dimension to FFR, Better Predict Post-PCI Results?
Circulation
August 2024
Cardiac Catheterization Laboratory (A.H.S.).
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