Characterization of the Cag pathogenicity island in Helicobacter pylori from naturally infected rhesus macaques.

FEMS Microbiol Lett

Departments of Medicine and of Microbiology & Immunology, Center for Comparative Medicine, California National Primate Research Center, University of California Davis, Davis, CA 95616, USA

Published: December 2016

Helicobacter pylori commonly infects the epithelial layer of the human stomach and in some individuals causes peptic ulcers, gastric adenocarcinoma or gastric lymphoma. Helicobacter pylori is a genetically diverse species, and the most important bacterial virulence factor that increases the risk of developing disease, versus asymptomatic colonization, is the cytotoxin associated gene pathogenicity island (cagPAI). Socially housed rhesus macaques are often naturally infected with H. pylori similar to that which colonizes humans, but little is known about the cagPAI. Here we show that H. pylori strains isolated from naturally infected rhesus macaques have a cagPAI very similar to that found in human clinical isolates, and like human isolates, it encodes a functional type IV secretion system. These results provide further support for the relevance of rhesus macaques as a valid experimental model for H. pylori infection in humans.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975239PMC
http://dx.doi.org/10.1093/femsle/fnw275DOI Listing

Publication Analysis

Top Keywords

rhesus macaques
16
helicobacter pylori
12
naturally infected
12
pathogenicity island
8
infected rhesus
8
pylori
6
characterization cag
4
cag pathogenicity
4
island helicobacter
4
pylori naturally
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!