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Home Urine Dipstick Screening for Bladder and Kidney Cancer in High-Risk Populations in England: A Microsimulation Study of Long-Term Impact and Cost-Effectiveness.
Pharmacoeconomics
January 2025
Sheffield Centre for Health and Related Research (SCHARR), School of Medicine and Population Health, The University of Sheffield, Regent Court, 30 Regent Street, Sheffield, UK.
Background: Testing high-risk populations for non-visible haematuria may enable earlier detection of bladder cancer, potentially decreasing mortality. This research aimed to assess the cost-effectiveness of urine dipstick screening for bladder cancer in high-risk populations in England.
Methods: A microsimulation model developed in R software was calibrated to national incidence data by age, sex and stage, and validated against mortality data.
Implementing a closed loop clinical decision support system for sustainable preoperative care.
NPJ Digit Med
January 2025
Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.
Unnecessary preoperative testing poses a risk to patient safety, causes surgical delays, and increases healthcare costs. We describe the effects of implementing a fully EHR-integrated closed-loop clinical decision support system (CDSS) for placing automatic preprocedural test orders at two teaching hospitals in Madrid, Spain. Interrupted time series analysis was performed to evaluate changes in rates of preoperative testing after CDSS implementation, which took place from September 2019 to December 2019.
View Article and Find Full Text PDFThe impact of risk compensation adaptive behavior on the final epidemic size.
Math Biosci
January 2025
Biocomplexity Institute, University of Virginia, VA, USA; Department of Computer Science, University of Virginia, VA, USA.
Public health interventions reduce infection risk, while imposing significant costs on both individuals and the society. Interventions can also lead to behavioral changes, as individuals weigh the cost and benefits of avoiding infection. Aggregate epidemiological models typically focus on the population-level consequences of interventions, often not incorporating the mechanisms driving behavioral adaptations associated with interventions compliance.
View Article and Find Full Text PDFNon-consumptive value of hilsa fishery restoration in West Bengal, India: An application of contingent valuation method.
J Environ Manage
January 2025
ICAR-Central Inland Fisheries Research Institute, Barrackpore, Kolkata, 700 120, India.
The study focuses on the socio-cultural importance of hilsa fishery in West Bengal, which extends beyond mere sustenance, symbolising heritage, identity, and community spirit, particularly in South 24 Parganas district. As the state fish and a crucial livelihood source for many fishers, grave concerns have recently been flagged due to reduced catches and increased prices, highlighting the need for restoration. This study seeks to measure the non-consumptive value of hilsa fishery by involving 200 participants, 100 fishers and 100 consumers, utilising the Contingent Valuation Method (CVM) with a payment card.
View Article and Find Full Text PDFCost-effectiveness analysis of pembrolizumab with chemotherapy for metastatic nonsquamous non-small cell lung cancer in Taiwan.
J Food Drug Anal
December 2024
Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
This study was aimed to evaluate the cost-effectiveness of pembrolizumab with chemotherapy (pembrolizumab combination therapy) and compare it with standard-of-care platinum-based chemotherapy (chemotherapy alone) as a first-line treatment for metastatic nonsquamous NSCLC from the perspective of Taiwan's third-party-payer public health-care system. We used a partitioned survival model with an estimated time horizon of 10 years. The partitioned survival model uses Kaplan-Meier estimates of progression-free and overall survival from the KEYNOTE-189 clinical trial.
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