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Mechanistic insights into retinoic-acid treatment for autism in the improvement of social behavior: Evidence from a multi omics study in rats.
Neuropharmacology
March 2025
Department of Child Health Care, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, 510623, China. Electronic address:
Background: Autism spectrum disorder (ASD) is a lifelong condition. It is characterized by complex etiologies, including disruptions in exogenous retinoic acid (RA) signaling, which may serve as an environmental risk factor. Targeting the RA pathway presents a promising therapeutic avenue, though the precise mechanisms remain to be elucidated.
View Article and Find Full Text PDFMyosin-5a facilitates stress granule formation by interacting with G3BP1.
Cell Mol Life Sci
October 2024
Group of Cell Motility and Muscle Contraction, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Stress granules (SGs) are non-membranous organelles composed of mRNA and proteins that assemble in the cytosol when the cell is under stress. Although the composition of mammalian SGs is both cell-type and stress-dependent, they consistently contain core components, such as Ras GTPase activating protein SH3 domain binding protein 1 (G3BP1). Upon stress, living cells rapidly assemble micrometric SGs, sometimes within a few minutes, suggesting that SG components may be actively transported by the microtubule and/or actin cytoskeleton.
View Article and Find Full Text PDFTranslatome analysis in acute ischemic stroke: Astrocytes and microglia exhibit differences in poststroke alternative splicing of expressed transcripts.
FASEB J
August 2024
Department of Neurology, National Center for Neurological Disorders, Xuanwu Hospital Capital Medical University, Beijing, China.
Article Synopsis
- This study investigates how astrocytes and microglia change after an ischemic stroke, focusing on alternative splicing (AS) of genes, which has not been extensively explored before.
- Researchers analyzed Ribo-Tag-seq data from male and female mice and found a significant increase in differential alternative splicing events, with astrocytes showing 109 events at 4 hours and 320 at 3 days poststroke, while microglia had 316 and 266, respectively.
- The research highlights how these alternative splicing events are connected to important functions like immune response and metabolism, revealing the complexity of the molecular responses in the brain after a stroke.
Spitz Melanoma With SLC20A1::ALK Fusion: A Novel Fusion Previously Undescribed in Spitz Melanocytic Neoplasm.
Am J Dermatopathol
October 2024
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Article Synopsis
- Spitz melanocytic neoplasms often have chromosomal rearrangements that lead to recurring gene fusions, primarily involving ALK, with key partners like TPM3 and DCTN1.
- While ALK fusions are mainly linked to Spitz nevi and atypical Spitz tumors, occurrences in Spitz melanoma are very rare.
- This study presents a unique case of Spitz melanoma featuring an SLC20A1::ALK fusion, alongside various chromosomal changes typical of melanoma and a mutation in GRM3.
BMP-2 regulates the expression of myosin Va via smad in melan-a melanocyte.
Arch Dermatol Res
May 2024
Department of Genetics & Biotechnology and Graduate School of Biotechnology, College of Life Science, Kyung Hee University, Yongin, 446-701, Gyeonggi-do, South Korea.
Myosin Va (Myo Va) is one of three protein complexes involved in melanosome transport. In this study, we identified BMP-2 as an up-regulator of Myo Va expression using 2-methyl-naphtho[1,2,3-de]quinolin-8-one (MNQO). Our results showed that MNQO reduced the mRNA and protein expression of Myo Va and BMP-2 in melanocytes.
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