AI Article Synopsis
- The study investigates how bacterial vaginosis might contribute to preterm birth through changes in miRNA expression linked to inflammation.
- It involved analyzing cervical swabs from 80 pregnant women, measuring bacterial presence, immune response (cytokine) levels, and 800 types of miRNAs during the mid-pregnancy period.
- Results show that higher bacterial and cytokine levels correlate with shorter pregnancy durations, suggesting specific miRNAs could be key indicators for understanding the risk of preterm birth.
Article Abstract
Aim: Bacterial vaginosis may lead to preterm birth through epigenetic programming of the inflammatory response, specifically via miRNA expression.
Methods: We quantified bacterial 16S rRNA, cytokine mRNA and 800 miRNA from cervical swabs obtained from 80 women at 16-19 weeks' gestation. We generated bacterial and cytokine indices using weighted quantile sum regression and examined associations with miRNA and gestational age at delivery.
Results & Discussion: Each decile of the bacterial and cytokine indices was associated with shorter gestations (p < 0.005). The bacterial index was associated with miR-494, 371a, 4286, 185, 320e, 888 and 23a (p < 0.05). miR-494 remained significant after false discovery rate correction (q < 0.1). The cytokine index was associated with 27 miRNAs (p < 0.05; q < 0.01).
Conclusion: Future investigation into the role of bacterial vaginosis- and inflammation-associated miRNA and preterm birth is warranted.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514975 | PMC |
| http://dx.doi.org/10.2217/epi-2016-0095 | DOI Listing |
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