Endothelial-mesenchymal transition (EndMT) drives endothelium to contribute to normal development and disease processes. Here, we report that EndMTs occur in the diabetic endothelium of Ins2Akita/wt mouse, and show that induction of sex determining region Y-box 2 (Sox2) is a mediator of excess BMP signaling that results in activation of EndMTs and increased vascular calcification. We also find an induction of a complex of serine proteases in the diabetic endothelium, required for the up-regulation of Sox2. Our results suggest that EndMTs contribute to vascular calcification in diabetic arteries.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148029 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167936 | PLOS |
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