Attraction to ethanol is common in both flies and humans, but the neuromodulatory mechanisms underlying this innate attraction are not well understood. Here, we dissect the function of the key regulator of serotonin signaling-the serotonin transporter-in innate olfactory attraction to ethanol in Drosophila melanogaster. We generated a mutated version of the serotonin transporter that prolongs serotonin signaling in the synaptic cleft and is targeted via the Gal4 system to different sets of serotonergic neurons. We identified four serotonergic neurons that inhibit the olfactory attraction to ethanol and two additional neurons that counteract this inhibition by strengthening olfactory information. Our results reveal that compensation can occur on the circuit level and that serotonin has a bidirectional function in modulating the innate attraction to ethanol. Given the evolutionarily conserved nature of the serotonin transporter and serotonin, the bidirectional serotonergic mechanisms delineate a basic principle for how random behavior is switched into targeted approach behavior.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147910 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167518 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Molecular Dynamics Simulation of the Compatibility Between Supercritical Carbon Dioxide and Coating Resins Assisted by Co-Solvents.
Materials (Basel)
December 2024
Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Institute of Environmental Science, Fudan University, Shanghai 200433, China.
The use of supercritical carbon dioxide (ScCO) as a replacement for volatile organic solvents in coatings has the potential to reduce air pollution. This paper presents the findings of a molecular dynamics simulation study investigating the dissolution behavior of polyvinylidene fluoride (PVDF) in ScCO assisted by five co-solvents. On the basis of solubility parameters, interaction binding energy, and radial distribution functions, the impacts of temperature, pressure, and co-solvents on the compatibility of ScCO and PVDF were investigated at the microscopic level.
View Article and Find Full Text PDFNovel sustainable biodiesel production from low-grade oleic acid via esterification catalyzed by characterized crystalline ZrO/AlO.
BMC Chem
January 2025
Petroleum Application Department, Egyptian Petroleum Research Institute (EPRI), Cairo, 11727, Egypt.
The depletion of fossil fuels and growing environmental concerns necessitate the exploration of renewable energy sources. Biodiesel, a promising alternative fuel derived from sustainable feedstock, has attracted considerable attention. This study investigates the catalytic esterification of oleic acid, a readily available fatty acid, with ethanol for biodiesel production using a novel heterogeneous catalyst, ZrO/AlO.
View Article and Find Full Text PDFDevelopment, and evaluation of film forming solutions for transdermal drug delivery of Zaltoprofen.
J Biomater Sci Polym Ed
December 2024
Department of Pharmaceutics, Dr. Prabhakar B Kore Basic Science Research Center, Off-campus, KLE College of Pharmacy (A constituent unit of KAHER-Belagavi), Bengaluru, Karnataka, India.
Zaltoprofen (ZAL) is a non-steroidal anti-inflammatory drug (NSAID) with a short half-life (∼2.8 h) due to extensive first pass metabolism. In this context, 16 different polymeric film forming solutions (PFFS) of ZAL were developed using different grades of Eudragits, Polyvinylpyrrolidones, Kollicoat MAE 100 P and Hydroxypropyl cellulose as film formers, and polyethylene glycol 400 as a plasticizer in equal parts of ethanol and isopropyl alcohol used as solvents.
View Article and Find Full Text PDFLipid mediator palmitoylethanolamide (PEA) inhibits pathogenic T cell differentiation in vitro and in vivo.
Biochem Biophys Res Commun
January 2025
Department of Infectious Disease Control, Faculty of Medicine, Oita University, Oita, 879-5593, Japan; Research Center for GLOBAL and LOCAL Infectious Diseases, Oita University, Oita, 879-5593, Japan. Electronic address:
Lipid mediator, palmitoylethanolamide (PEA) has recently attracted attention as a potential therapeutic option for various inflammatory autoimmune diseases. It has been reported that PEA exerts an inhibitory effect on inflammation triggered by PRRs, particularly Toll-like receptors expressed on myeloid antigen-presenting cells. However, the precise role of PEA in T cell development and function has not yet been elucidated.
View Article and Find Full Text PDFPt-Decorated ZnO Nanorods for Light-Assisted Ethanol Sensing and Analysis of the Sensing Mechanism under Light Irradiation.
ACS Appl Mater Interfaces
December 2024
Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto 860-8555, Japan.
ZnO nanorods have attracted much attention owing to their outstanding properties for chemical gas sensors. Although they show greater sensing properties than conventional nanoparticulate ZnO, high operation temperature (>250-350 °C) is required for them to work even if precious metals are deposited on them to sensitize their sensing properties. Light irradiation is one solution for overcoming the high operation temperature and the gas selectivity because it assists the oxidation activity on the surface that affects the sensor response.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!