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Inhibition of Interleukin-6 Receptor in a Murine Model of Myocardial Ischemia-Reperfusion. | LitMetric

AI Article Synopsis

  • Interleukin-6 (IL-6) levels increase during heart attacks, and researchers studied whether blocking the IL-6 receptor (IL-6R) with a monoclonal antibody (MR16-1) could protect the heart from damage after ischemia-reperfusion injury in mice.
  • Mice were administered MR16-1 or a control after a heart injury, and after four weeks, their heart functions and structural changes were analyzed using cardiac imaging and hemodynamic assessments.
  • The results showed that blocking IL-6R did not prevent heart remodeling after injury; in fact, it was linked to worse outcomes in heart function compared to controls, indicating a potentially harmful effect of this treatment.

Article Abstract

Background: Interleukin-6 (IL-6) levels are upregulated in myocardial infarction. Recent data suggest a causal role of the IL-6 receptor (IL-6R) in coronary heart disease. We evaluated if IL-6R blockade by a monoclonal antibody (MR16-1) prevents the heart from adverse left ventricular remodeling in a mouse model of ischemia-reperfusion (I/R).

Methods: CJ57/BL6 mice underwent I/R injury (left coronary artery ligation for 45 minutes) or sham surgery, and thereafter received MR16-1 (2mg/mouse) 5 minutes before reperfusion and 0.5mg/mouse weekly during four weeks, or control IgG treatment. Cardiac Magnetic Resonance Imaging (CMR) and hemodynamic measurements were performed to determine cardiac function after four weeks.

Results: I/R caused left ventricular dilatation and a decrease in left ventricular ejection fraction (LVEF). However, LVEF was significantly lower in the MR16-1 treatment group compared to the IgG group (28±4% vs. 35±6%, p = 0.02; sham 45±6% vs. 43±4%, respectively; p = NS). Cardiac relaxation (assessed by dP/dT) was not significantly different between the MR16-1 and IgG groups. Also, no differences were observed in histological myocardial fibrosis, infarct size and myocyte hypertrophy between the groups.

Conclusion: Blockade of the IL-6R receptor by the monoclonal MR16-1 antibody for four weeks started directly after I/R injury did not prevent the process of cardiac remodeling in mice, but rather associated with a deterioration in the process of adverse cardiac remodeling.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147868PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167195PLOS

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