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Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency. | LitMetric

AI Article Synopsis

  • Sulforaphane (SF) from broccoli is a powerful compound known for activating the body's protective responses and is marketed in supplements.
  • Two stabilized versions of SF were tested for stability and effectiveness: SF-αCD and a commercial supplement.
  • While both preparations were effective in cultured cells, SF-αCD caused mild stomach issues and was not effective on skin, indicating a need for further research on similar health products.

Article Abstract

Scope: The isothiocyanate sulforaphane (SF) from broccoli is one of the most potent known inducers of the cytoprotective phase 2 response. Its role in a host of biochemical pathways makes it a major component of plant-based protective strategies for enhancing healthspan. Many nutritional supplements are now marketed that purport to contain SF, which in plants exists as a stable precursor, a thioglucoside hydroxysulfate. However, SF in pure form must be stabilized for use in supplements.

Methods And Results: We evaluated the stability and bioavailability of two stabilized SF preparations-an α-cyclodextrin inclusion (SF-αCD), and an SF-rich, commercial nutritional supplement. SF-αCD area-under-the-curve peak serum concentrations occurred at 2 h, but six of ten volunteers complained of mild stomach upset. After topical application it was not effective in upregulating cytoprotective enzymes in the skin of SKH1 mice whereas pure SF was effective in doing so. Both of these "stabilized" SF preparations were as potent as pure SF in inducing the cytoprotective response in cultured cells, and they were more stable and as bioavailable.

Conclusion: Our studies of a stabilized phytochemical component of foods should encourage further examination of similar products for their utility in chronic disease prevention and therapy.

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Source
http://dx.doi.org/10.1002/mnfr.201600766DOI Listing

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