Access to 4-Oxazolidinones: A (3 + 2) Cycloaddition Approach.

Org Lett

Department of Chemistry, University of Nevada, Reno, Nevada 89557-0216, United States.

Published: December 2016

The novel reactivity of in situ generated aza-oxyallyl cation intermediates with a variety of carbonyl compounds is reported to construct 4-oxazolidinones motifs with good yields and diastereoselectivities. This simple and efficient (3 + 2) cycloaddition method provides direct access to potential bioactive compounds.

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Source
http://dx.doi.org/10.1021/acs.orglett.6b03069DOI Listing

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