The Eastern Cooperative Oncology Group undertook a limited institution phase II study of PCNU in advanced, metastatic breast cancer. The study was limited to patients treated with 1 to 2 prior chemotherapy regimens. Accrual goals were 30 patients but the study was terminated after 10 patients had no response, with a rapid time to progression of 4 weeks, despite considerable hematologic toxicity. Based on this experience and negative results in two prior studies in more heavily pretreated patients, we conclude PCNU is inactive in breast cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF00170866 | DOI Listing |
Publication Analysis
Top Keywords
breast cancer
8
phase trial
4
trial pcnu
4
pcnu breast
4
breast carcinoma
4
carcinoma eastern
4
eastern cooperative
4
cooperative oncology
4
oncology group
4
group undertook
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!