Much effort is being made to quantitate and improve the outcomes associated with medical treatment. These outcomes are defined as how the patient did after an intervention and may be termed "value on the back end" of the treatment process. The diagnosis guides the content and timing of the treatment, and may be considered the "value on the front end" that optimizes the treatment process. The diagnosis can be defined as "that body of information, collected through the process of evaluating the patient's health problem, that determines the content and timing of the treatment of the health problem." An Institute of Medicine monograph has documented "troubling" deficiencies in the diagnostic process and has suggested guidelines to establish a comprehensive and effective diagnosis, which should include anatomic and patient-derived factors, have multidisciplinary input, have implications for treatment content and timing, and relate to outcomes. The monograph establishes a linear relationship and direct linkage between the diagnosis and treatment. There is much evidence in orthopaedics that these deficiencies exist and often limit the implementation of the most beneficial treatments. Efforts should be made to improve the effectiveness of the diagnostic process to optimize the entire treatment process. The 5 A's framework can be used as a template for the accumulation of information that can guide the treatment process.
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http://dx.doi.org/10.1016/j.arthro.2016.09.010 | DOI Listing |
Water Res
January 2025
State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco- Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:
The flow through the grit chamber is non-biochemically treated wastewater, which contains microorganisms mainly from the source of wastewater generation. There are limited reports on aerosol particles generated by grit chambers compared with those produced by biochemical treatment tanks. This study analyzed the fugitive characteristics of aerosol particles produced in grit chambers at nine wastewater treatment plants in three regions of China.
View Article and Find Full Text PDFWater Res
January 2025
Faculty of Geosciences and Civil Engineering, Kanazawa University, Kanazawa 920-1192, Japan; Center for Infectious Disease Education and Research (CiDER), Osaka University, 565-0871, Japan. Electronic address:
Treated effluent of wastewater treatment plants (WWTPs) are major sources of extracellular antimicrobial resistance genes (eARGs) into aquatic environments. This study aimed to clarify the fate and origins of eARGs from influent to treated effluent at a full-scale WWTP. The compositions of eARG and intracellular ARG (iARG) were acquired via shotgun metagenomic sequencing in influent wastewater, activated sludge, and treated effluent of the target WWTP, where identical wastewater was treated by conventional activated sludge (CAS) and membrane bioreactor (MBR) processes.
View Article and Find Full Text PDFBiomed Phys Eng Express
January 2025
Chiba University Center for Frontier Medical Engineering, 1-33 Yayoi-cho, Inage-ku, Chiba, Chiba, 263-8522, JAPAN.
Traumatic injury remains a leading cause of death worldwide, with traumatic bleeding being one of its most critical and fatal consequences. The use of whole-body computed tomography (WBCT) in trauma management has rapidly expanded. However, interpreting WBCT images within the limited time available before treatment is particularly challenging for acute care physicians.
View Article and Find Full Text PDFJ Med Food
January 2025
Department of Infectious Diseases and Liver Diseases, Ningbo Medical Centre Lihuili Hospital, Affiliated Lihuili Hospital of Ningbo University, Ningbo, China.
Disturbances of the intestinal barrier enabling bacterial translocation exacerbate alcoholic liver disease (ALD). GG (LGG) has been shown to exert beneficial effects in gut dysbiosis and chronic liver disease. The current study assessed the combined effects of LGG and metformin, which play roles in anti-inflammatory and immunoregulatory processes, in alcohol-induced liver disease mice.
View Article and Find Full Text PDFMedicine (Baltimore)
January 2025
Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, PR China.
Rationale: Bilateral gluteus medius contractures in adults are rare in clinical practice, with only a few cases reported. These contractures may result from repeated intramuscular injections during childhood. Understanding the clinical manifestations, diagnostic process, treatment, and outcomes can provide insights into effective management strategies.
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