Chemical investigation of the stems of Epigynum auritum led to the isolation and identification of a novel 16,17-seco pregnane glycoside, epigynoside D, along with other three known compounds (2-4). The structure of compound 1 was elucidated by means of spectroscopic analysis, including HRESIMS, 1D and 2D NMR experiments. All isolated compounds were tested for their in vitro cytotoxic, immunological and anti-acetylcholinesterase activities.
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Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity.
Phytochemistry
December 2019
Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China. Electronic address:
Five undescribed C pregnane glycosides, epigycosides D-H, together with four known analogues, two lignans, and a flavonoid have been isolated from the stems of Epigynum cochinchinensis. The structures of pregnane glycosides were elucidated using spectroscopic techniques and acid hydrolysis. The in vitro immunological activities were assessed against Con A-stimulated proliferation of mice splenocytes.
View Article and Find Full Text PDFA immunosuppressive triterpenoid saponin from the stems of .
Nat Prod Res
May 2020
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming, Yunnan, People's Republic of China.
Chemical investigation of the stems of led to the isolation and identification of a new triterpenoid saponin () and two known compounds (epigynosides A () and B ()). These structures were elucidated by means of spectroscopic analysis (1D and 2D NMR, MS, UV, IR) as well as comparison with the reported data. Compound 1 was evaluated in vitro for the immunosuppressive activities on proliferation of mice splenocyte and displayed significant immunosuppressive activities compared to the positive control (dexamethasone) with the concentration at 25 μM.
View Article and Find Full Text PDFA new immunosuppressive pregnane glycoside from aqueous fraction of Epigynum cochinchinensis.
Nat Prod Res
December 2017
a Kunming University of Science and Technology , Yunnan Institute of Food Safety, Kunming , People's Republic of China.
Chemical investigation on the aqueous fraction of the stems of Epigynum cochinchinensis led to the isolation of a new pregnane glycoside named as epigycoside A (1) along with three known analogues (2-4). The structure of compound 1 was elucidated by means of spectroscopic techniques, including HRESIMS, and 1D and 2D NMR experiments. The immunosuppressive activity of 1 was evaluated by an in vitro model of concanavalin A-induced mice splenocytes proliferation.
View Article and Find Full Text PDFSeco-pregnane glycosides from the stems of Epigynum auritum.
Nat Prod Res
May 2017
a Yunnan Institute of Food Safety , Kunming University of Science and Technology, Kunming , People's Republic of China.
Chemical investigation of the stems of Epigynum auritum led to the isolation and identification of a novel 16,17-seco pregnane glycoside, epigynoside D, along with other three known compounds (2-4). The structure of compound 1 was elucidated by means of spectroscopic analysis, including HRESIMS, 1D and 2D NMR experiments. All isolated compounds were tested for their in vitro cytotoxic, immunological and anti-acetylcholinesterase activities.
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