Ocular neuromyotonia (ONM) is a neuro-ophthalmic disorder characterized by episodic diplopia caused by contraction of one or more ocular muscles due to spontaneous excitation of the respective ocular motor nerve. We report a patient whose ocular neuromyotonia arose in the setting of a subacute demyelinating polyneuropathy consistent with chronic inflammatory demyelinating polyneuropathy (CIDP) and subsequently resolved following the initiation of intravenous immunoglobulin (IVIg) for her neuropathy. Our patient provides additional evidence towards the role of demyelination and ephaptic neurotransmission in ocular neuromyotonia and also represents the first reported case of ocular neuromyotonia associated with a systemic neurological condition.
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http://dx.doi.org/10.3109/01658107.2015.1059464 | DOI Listing |
J AAPOS
December 2024
Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts. Electronic address:
A man in his 60s developed an intermittent, variable left hypotropia with symptomatic diplopia following nasal pterygium surgery in the left eye. No tropia was present for most of the day, but a variable left hypotropia of 25 could be provoked with downgaze. There was no history of radiation or other trauma.
View Article and Find Full Text PDFJ Neuroophthalmol
December 2024
Department of Neurology (HJ), Soonchunhyang University Seoul Hospital, Seoul, South Korea; Department of Neurology (E-SL, J-SL, S-KL), Soonchunhyang University Bucheon Hospital, Bucheon, South Korea; and Department of Neurology (J-SK), Seoul National University Bundang Hospital, Seoul, South Korea.
J Neuroophthalmol
April 2024
Department of Ophthalmology (SAH, ABG), American University of Beirut, Beirut, Lebanon; and Department of Ophthalmology (SY), Moorfields Eye Hospital Dubai, Dubai, United Arab Emirates.
Arch Soc Esp Oftalmol (Engl Ed)
May 2024
Departamento de Estrabismo y Oftalmología Pediátrica, Hospital Universitario Lucus Augusti, Lugo, Spain.
Ocular neuromyotonia (ONM) is an infrequent disorder characterised by recurrent episodes of binocular diplopia caused by paroxysmal contraction of one or several extraocular muscles innervated by the same cranial nerve. It can be triggered spontaneously or caused by prolonged contraction of specific eye muscle(s) and is usually related to a local intracranial radiotherapy antecedent. We report the case of a 46-year-old woman who developed intermittent episodes of binocular diplopia eight years after radiotherapy for a nasopharyngeal carcinoma.
View Article and Find Full Text PDFAm J Ophthalmol
July 2024
From the Department of Ophthalmology, Mayo Clinic College of Medicine (T.B.B., L.D.K., A.M.K., J.A.L., J.A.G., S.A.M.), Rochester, Minnesota; Departments of Ophthalmology, Mayo Clinic Health Systems (S.A.M.), Eau Claire, Wisconsin, USA. Electronic address:
Purpose: The purpose of this study was to describe the clinical features, management, outcomes, and diagnostic pitfalls in a large series of patients with ocular neuromyotonia.
Design: Retrospective cohort.
Methods: Patients diagnosed with ocular neuromyotonia from January 1, 2004, through January 1, 2023, seen at one of the 3 Mayo Clinic sites in Rochester, MN, Scottsdale, AZ, and Jacksonville, FL, comprised the study population.
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