Purpose: To investigate the causes and prevention of distal adding on in Lenke 1A scoliosis.
Methods: Sixty Lenke 1A patients were included. The authors selected 10 potential risk factors for distal adding on. Postoperative increase in 5 radiographic parameters was used to indicate the extent of distal adding on. The authors then performed correlation analysis between the 10 potential risk factors and the extent of distal adding on, with the aim of identifying the causes of distal adding on. To predict 2-year outcome using preoperative parameters, linear regression models were established. The authors selected 2-year Cobb angle, thoracic apical vertebra center sacral vertical line (CSVL) distance and lowest instrumented vertebra (LIV)-CSVL distance to represent 2-year outcome. Their correlations with 8 preoperative parameters were tested.
Results: Potential risk factors representing either LIV selection or skeletal immaturity were highly correlated with the 5 radiographic parameters, which suggests that LIV selection and skeletal immaturity are causative in connection with distal adding on. The formula for predicting 2-year LIV-CSVL distance was: 2-year LIV-CSVL distance = 9.9 + 0.8 (preoperative LIV-CSVL distance) - 4.2 (Risser sign grade). The model adjusted R = 0.77.
Conclusions: In Lenke 1A scoliosis, both LIV selection and skeletal immaturity are highly correlated with distal adding on. In other words, the shorter the extent is of distal fusion, the larger is the distal adding on; the less skeletally mature the patient is, the larger is the distal adding on. When treating skeletally immature patients (Risser sign ≤3) with 1A curves, performing fusion surgeries should be avoided when possible; growing rod treatment may be the optimal treatment choice. For skeletally mature patients, LIV selection should be the first consideration; the preoperative LIV-CSVL distance should be ≤21 mm when the Risser sign grade is 4 and ≤ 26 mm when the Risser sign grade is 5.
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http://dx.doi.org/10.1016/j.jspd.2014.04.003 | DOI Listing |
Acta Neurochir (Wien)
January 2025
Department of Orthopaedics & Traumatology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
Background: The aim of this study is to examine the association between adding-on (AO) and disc degeneration(DD) of distal unfused levels in Lenke 3 C, 5 C, 6 C adolescent idiopathic scoliosis (AIS) patients with a follow-up of at least two years by comparing preoperative and postoperative magnetic resonance imaging (MRI).
Methods: 47 AIS patients (32 females and 15 males) with structural thoracolumbar/lumbar (TL/L) curves treated with long segment thoracolumbar fusion were retrospectively evaluated. Patients were divided into two groups according to the occurrence of the AO (AO and Non-AO groups).
Eur Spine J
December 2024
Department of Orthopaedic Surgery, Faculty of Medicine, National Orthopaedic Centre of Excellence for Research and Learning (NOCERAL), Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Purpose: To devise a mathematical model for estimating the intraoperative lowest instrumented vertebra (LIV) tilt angle using preoperative supine left side-bending (LSB) radiographs in adolescent idiopathic scoliosis (AIS) patients with Lenke type 1 and 2 (non-AR curves), and to review its clinical and radiological outcomes.
Methods: The mathematical model for the adjusted LSB LIV tilt angle (α) measured preoperatively, was expressed as the sum of preoperative LSB LIV tilt angle (x) and LIV displacement angle (y) (α = x + y). This model was validated through inter-rater and intra-rater analysis in Part I of the study.
Pancreatology
December 2024
Department of Gastroenterology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Background/objectives: Positive pancreatic juice cytology (PJC) is an important finding when considering surgical resection in patients with intraductal papillary mucinous neoplasm (IPMN); however, guidelines do not recommend endoscopic retrograde cholangiopancreatography (ERCP) for PJC. This study aimed to clarify the findings worthy of adding PJC for diagnosing high-grade dysplasia (HGD) and invasive carcinoma (IC) in patients with IPMN.
Methods: Patients with IPMN who underwent preoperative PJC and surgical resection at Hiroshima University Hospital were enrolled, and the diagnostic yield of malignant IPMN based on PJC and clinical and imaging findings and the incidence of post-ERCP pancreatitis (PEP) were retrospectively analyzed.
Pathol Res Pract
December 2024
University of Alabama at Birmingham, Department of Pathology, United States. Electronic address:
Hirschsprung's (HSCR) disease, also known as aganglionic megacolon, or congenital intestinal aganglionosis affects roughly 1 out of every 5000 newborns. It is a birth defect characterized by the partial or complete loss of ganglion cells in the myenteric and submucosal plexus of the distal intestine which leads to ineffective peristalsis, constipation, and obstruction. Clinical assessment and radiological observations might imply HSCR disease, but definitive diagnosis requires biopsy interpretation and confirmation of ganglion cell loss.
View Article and Find Full Text PDFScand J Med Sci Sports
December 2024
Department of Public Health, Lifestyles and Living Environments Unit, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
This study investigated longitudinal physical activity (PA) profiles over 7 years in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER). Cognition, depression, pain, and PA motives were included as determinants of the PA profiles. The 1259 participants, aged 60-77 years at baseline, were randomized into either a control group receiving general health advice, or an intervention group offered a comprehensive 2-year multidomain intervention including physical exercise, diet advice, cognitive training, and vascular risk factor management.
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