What's the Key to Unlocking the Proteasome's Gate?

Structure

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA. Electronic address:

Published: December 2016

In this issue of Structure, Bolten et al. (2016) describe the organization of the mycobacterial proteasome in complex with the ATP-independent bacterial proteasome activator (Bpa, PafE). They confirm several activation motifs employed by archaea and eukaryotes and highlight differences that pose Bpa as a novel architectural class of proteasome activators.

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http://dx.doi.org/10.1016/j.str.2016.11.011DOI Listing

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