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Mechanisms of action of ethyl acetate fractions of Liparis nervosa (Thunb.) Lindl. as potential central anti-nociceptive agents.
Inflammopharmacology
December 2024
School of Pharmacy, Southwest Minzu University, Chengdu, China.
Opioids/non-steroidal anti-inflammatory drugs are used to alleviate pain; however, they are expensive and can have adverse effects, especially when used over extended periods. Therefore, there is immense demand for innovative, non-addictive analgesics. Here, we report a novel plant-derived central anti-nociceptive agent, Liparis nervosa (Thunb.
View Article and Find Full Text PDFTrifluoro-Icaritin Ameliorates Neuroinflammation Against Complete Freund's Adjuvant-Induced Microglial Activation by Improving CB2 Receptor-Mediated IL-10/β-endorphin Signaling in the Spinal Cord of Rats.
J Neuroimmune Pharmacol
October 2024
Department of Physiology, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou, 341000, P. R. China.
The underlying pathogenesis of chronic inflammatory pain is greatly complex, but the relevant therapies are still unavailable. Development of effective candidates for chronic inflammatory pain is highly urgent. We previously identified that trifluoro-icaritin (ICTF) exhibited a significant therapeutic activity against complete Freund's adjuvant (CFA)-induced chronic inflammatory pain, however, the precise mechanisms remain elusive.
View Article and Find Full Text PDFDeletion of arrestin-3 does not reduce drug-seeking behavior in a longitudinal paradigm of oral morphine self-administration.
Front Pharmacol
September 2024
Center for Neuroscience, University of California-Davis, Davis, CA, United States.
Article Synopsis
- Opioid drugs activate the µ-opioid receptor, mimicking natural pain-relieving peptides, but their use is limited due to side effects and the risk of opioid use disorder.
- The study examined how different levels of arrestin-3 recruitment to the µ-opioid receptor in mice affected their drug-seeking behavior, revealing that mice without arrestin-3 showed more compulsive tendencies.
- The findings suggest that opioids activating both G proteins and arrestin-3 could lead to decreased risk of abuse, indicating a potential pathway for improving pain management without increasing addiction risk.
MP-13, a novel chimeric peptide of morphiceptin and pepcan-9, produces potent antinociception with limited side effects.
Neuropeptides
October 2024
Department of Animal and Biomedical Sciences, School of Life Sciences, Lanzhou University, 222 Tianshui South Road, Lanzhou 730000, China; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, 222 Tianshui South Road, Lanzhou 730000, China. Electronic address:
Pharmacological investigations have substantiated the potential of bifunctional opioid/cannabinoid agonists in delivering potent analgesia while minimizing adverse reactions. Peptide modulators of cannabinoid receptors, known as pepcans, have been investigated before. In this study, we designed a series of chimeric peptides based on pepcans and morphiceptin (YPFP-NH).
View Article and Find Full Text PDFdecoction alleviates primary dysmenorrhoea symptoms in a rat model.
J Obstet Gynaecol
December 2024
Department of Gynaecology, Taicang Traditional Chinese Medicine Hospital, Affiliated to Nanjing University of Chinese Medicine, Taicang, Jiangsu, China.
Background: Existing treatments for primary dysmenorrhoea (PD), such as NSAIDs, impart side effects. decoction (GGD), a traditional Chinese medicine, has shown promise in treating PD, but its exact mechanisms remain unclear. Here, we aimed to investigate the efficiency of GGD in alleviating PD using a rat model to understand its precise mechanism of action.
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