The structural-functional state of the left ventricle of boys aged 8-12 years going in for middle-distance racing (the 1st group), swimming (the 2nd group) and wrestling (the 3rd group) has been studied by the method of echo-, poly- and electrocardiography. It is found that posterior wall of the ventricle myocardium is thicker, size of its anteroposterior cavity as well as cavity volume and total volume are larger, the myocardium mass is higher in younger sportsmen as compared with non-sportsmen of the same age. These data indicate the development of ventricular hyperfunction in both isometric and isotonic regimes. In trained pupils the heart rate is lower, all the phases of total systole are longer, intrasystolic value is smaller, and myocardium tension index is higher. They are the indicators of economy development in ventricular activity. These differences are the most significant in children developing their endurance.
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J Am Heart Assoc
January 2025
The Center for Vascular Disease and Translational Medicine, The Third Xiangya Hospital Central South University Changsha Hunan China.
Background: Pulmonary arterial hypertension (PAH) is an incurable disease initiated by endothelial dysfunction, secondary to vascular inflammation and occlusive pulmonary arterial vascular remodeling, resulting in elevated pulmonary arterial pressure and right heart failure. Previous research has reported that dysfunction of type 2 bone morphogenetic protein receptor (BMPR2) signaling pathway in endothelium is inclined to prompt inflammation in PAH models, but the underlying mechanism of BMPR2 deficiency-mediated inflammation needs further investigation. This study was designed to investigate whether BMPR2 deficiency contributes to pulmonary arterial hypertension via the NLRP3 (NOD-like receptor family protein 3)/GSDME (gasdermin E)-mediated pyroptosis pathway.
View Article and Find Full Text PDFEur Heart J Digit Health
January 2025
Department of Cardiovascular Surgery of Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Aims: Accurate heart function estimation is vital for detecting and monitoring cardiovascular diseases. While two-dimensional echocardiography (2DE) is widely accessible and used, it requires specialized training, is prone to inter-observer variability, and lacks comprehensive three-dimensional (3D) information. We introduce CardiacField, a computational echocardiography system using a 2DE probe for precise, automated left ventricular (LV) and right ventricular (RV) ejection fraction (EF) estimations, which is especially easy to use for non-cardiovascular healthcare practitioners.
View Article and Find Full Text PDFBreathe (Sheff)
January 2025
Université Paris-Saclay, INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), Faculté de Médecine, Le Kremlin-Bicêtre, France.
Pulmonary arterial hypertension (PAH) is a severe disorder of the pulmonary vasculature leading to right ventricular failure. This pulmonary vascular remodelling leads to increased pulmonary vascular resistance and high pulmonary arterial pressures. Despite the development of new therapies, many patients continue to experience significant morbidity and mortality.
View Article and Find Full Text PDFCureus
December 2024
Department of Cardiology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, IRN.
Pulmonary thromboembolism (PTE) is the third most common cause of acute cardiovascular disease, which can lead to high morbidity and mortality if left untreated. Anatomical and electrophysiological variations and obesity may complicate timely diagnosis and delay required management. While computed tomography pulmonary angiography (CTPA) remains the most accurate diagnostic tool, initial assessments using electrocardiography (ECG) or echocardiography can be helpful in early suspicion.
View Article and Find Full Text PDFCureus
December 2024
Department of Cardiology, Maimonides Medical Center, New York, USA.
The safety of traditional Chinese medicine (TCM) herbal remedies, particularly when used with modern medications or in non-traditional dosages, requires careful consideration. We present a case of a 62-year-old male with pre-existing cardiovascular risk factors who developed tachycardia-induced cardiomyopathy (TIC) potentially linked to prolonged use of the TCM supplement "Tan Ke Jing." The supplement contains licorice root, caffeine, and apricot kernel, which have known cardiovascular effects.
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