Adenine- and riboxine-containing erythropifaden has been studied for possibility to be used for restoring a functional value of erythrocytes in conserved donor blood stored for 35-49 days. Energy supply and oxygen transport function of erythrocytes are shown to get normal and their morphological composition--to get considerably improved. Besides, osmotic resistance and deformability of erythrocytes insignificantly change while concentration of riboxine in blood and that of substances with average molecular mass remain considerably high. One of the ways to remove the above shortcomings is application of hemosorbents.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
OPG and BAFF as predictive biomarkers of the severity of SARS-CoV-2 infection.
J Cell Mol Med
February 2025
Research Unit, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
Molecules of the tumour necrosis factor superfamily (TNFSF) are key players in immune regulation; an increase in some TNFSF molecules has been reported during severe COVID-19. In this study, we profiled and evaluated TNFSF members in the serum of COVID-19 vaccine-naïve patients to identify potential biomarkers associated with disease severity. Our data show that TRAIL serum levels are lower in severely affected patients than those mildly affected by COVID-19 (AUC 0.
View Article and Find Full Text PDFBioprinting Perfusable and Vascularized Skeletal Muscle Flaps for the Treatment of Volumetric Muscle Loss.
Adv Healthc Mater
January 2025
Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, 3200003, Israel.
Volumetric muscle loss (VML) refers to muscle tissue loss exceeding 20% within a functional area due to trauma or surgery, often leading to physical disabilities. VML treatment relies on the transplantation of autologous flaps harvested from a healthy-donor site while minimizing the probability of immune rejection. However, this approach often leads to donor-site morbidity and relies on a restricted supply of muscle tissue.
View Article and Find Full Text PDFElevated plasma testosterone concentrations from males on testosterone replacement therapy are mitigated with pathogen reduction technology.
Transfusion
January 2025
Transfusion Medicine, ARUP Laboratories, Salt Lake City, Utah, USA.
Background: Donors on testosterone replacement therapy (TRT) may require frequent whole blood donation due to erythrocytosis, but FDA guidelines prevent the transfusion of plasma-based products from these donors. This study surveyed TRT donor testosterone levels in whole blood components and evaluated a possible mitigation strategy with a pathogen reduction technology using UVA light and compound adsorption device (CAD) steps.
Study Design And Methods: Whole blood from male TRT donors and controls were processed into red blood cells and plasma components.
Frequent apheresis donation is not associated with adverse bone health in donors aged 45 years and over-Results from a cohort study in Australia.
Transfusion
January 2025
Research and Development, Australian Red Cross Lifeblood, Sydney, New South Wales, Australia.
Background: We investigated whether frequent apheresis donors have altered risk of bone fractures, and prescription of osteoporosis medicine//s due to their repeated exposure to citrate anticoagulant.
Methods: We used the Sax Institute's 45 and Up Study data linked with blood donation and other health-related datasets. We used a "5-year qualification period" method to identify active donors who donated at least one (any type) donation in the first and fifth year of the "qualification period.
Long-term survival and clinical implications of allogeneic stem cell transplantation in relapse/refractory lymphoma: A 20-year Singapore experience.
Ann Acad Med Singap
December 2024
Department of Haematology, Singapore General Hospital, Singapore.
Introduction: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a curative option for relapse/refractory (R/R) lymphomas that have failed autologous transplantation or for high-risk lymphomas in the upfront setting. We conducted a retrospective analysis on consecutive lymphoma patients who underwent allo-HSCT over a 20-year period (2003- 2022) at Singapore General Hospital and National University Hospital Singapore.
Method: A total of 121 patients were included in the study.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!