AI Article Synopsis
- Acute and chronic liver injuries lead to the death and turnover of liver cells (hepatocytes), which can result in serious conditions like cirrhosis and liver cancer if not controlled.
- Controlling liver cell death through therapies is crucial to prevent acute liver failure and manage chronic inflammation and fibrosis caused by ongoing cell death.
- The role of necroptosis, a specific type of regulated cell death, in liver disease is still debated, with recent studies showing mixed results, prompting further research in this area.
Article Abstract
Acute and chronic liver injury results in hepatocyte death and turnover. If injury becomes chronic, the continuous cell death and turnover leads to chronic inflammation, fibrosis and ultimately cirrhosis and hepatocellular carcinoma. Controlling liver cell death both in acute injury, to rescue the liver from acute liver failure, and in chronic injury, to curb secondary inflammation and fibrosis, is of paramount importance as a therapeutic strategy. Both apoptosis and necrosis occur in the liver, but the occurrence of necroptosis in the liver and its contribution to liver disease is controversial. Necroptosis is a form of regulated necrosis which occurs in certain cell types when caspases (+/-cIAPs) are inhibited through the RIPK1-RIPK3 activation of MLKL. The occurrence of necroptosis in the liver has recently been examined in multiple liver injury models with conflicting results. The aim of this review is to summarize the published data with an emphasis on the controversies and remaining questions in the field.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136616 | PMC |
| http://dx.doi.org/10.1038/cddiscovery.2016.89 | DOI Listing |
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