AI Article Synopsis
- Glioma is an aggressive brain tumor that's common in adults, with the role of long-non coding RNAs (lncRNAs) in glioma not being well understood.
- In this study, researchers found that lncRNA CCND2-AS1 is significantly increased in glioma tissues and cells, leading to enhanced cell proliferation and growth.
- The study suggests that CCND2-AS1 activates Wnt/β-catenin signaling, indicating its potential as a novel target for glioma treatment.
Article Abstract
Glioma is the most common and aggressive primary brain tumor in adults. Long-non coding RNAs (lncRNAs) have been recently shown to play important roles in regulating numerous biological processes both in physiologic and pathologic condition. However, the role of lncRNAs in glioma remains largely unknown. In this study, we firstly found that lncRNA CCND2-AS2 is significantly up regulated in malignant glioma tissues and cell lines. Both loss- and gain-functions assays show that CCND2-AS1 promotes glioma cells proliferation and growth. In addition, we also revealed that highly expressed CCND2-AS1 could enhance Wnt/β-catenin signaling in glioma. Taken together, our findings revealed a novel lncRNA CCND2-AS1 promotes glioma cell proliferation through Wnt/β-catenin signaling and CCND2-AS1 might function as a potential novel therapeutic target for the treatment of glioma.
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| http://dx.doi.org/10.1016/j.bbrc.2016.12.016 | DOI Listing |
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