AI Article Synopsis
- MicroRNAs (miRNAs) play a crucial role in regulating gene expression and are also involved in inter-cellular signaling, which expands their biological significance.
- MiRNAs can survive outside of cells in bodily fluids and remain functional when taken up by other cells, allowing them to influence gene expression in those cells.
- Understanding how miRNAs mediate communication between cells could lead to new insights into disease development and open up potential therapeutic avenues, particularly in metabolic diseases and cancers.
Article Abstract
The contribution of microRNAs to the regulation of mRNA expression during physiological and developmental processes are well-recognized. These roles are being expanded by recent observations that emphasize the capability of miRNA to participate in inter-cellular signaling and communication. Several factors support a functional role for miRNA as mediators of cell-to-cell signaling. miRNA are able to exist within the extracellular milieu or circulation, and their stability and integrity maintained through association with binding proteins or lipoproteins, or through encapsulation within cell-derived membrane vesicles. Furthermore, miRNA can retain functionality and regulate target gene expression following their uptake by recipient cells. In this overview, we review specific examples that will highlight the potential of miRNA to serve as paracrine signaling mediators in metabolic diseases and cancers. Elucidating the mechanisms involved in inter-cellular communication involving miRNA will provide new insights into disease pathogenesis and potential therapeutic opportunities.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147504 | PMC |
| http://dx.doi.org/10.1016/j.beem.2016.07.005 | DOI Listing |
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