Evolution: Enhanced Footing for Snake Limb Development.

Curr Biol

Cancer and Developmental Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA. Electronic address:

Published: December 2016

Two groups have studied the loss of limbs in snake evolution by focusing on a long-distance cis-acting enhancer of Sonic Hedgehog. They find a progressive degeneration of binding sites for key transcription factors, mirroring the progressive limblessness occurring in these reptiles.

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http://dx.doi.org/10.1016/j.cub.2016.10.018DOI Listing

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