AI Article Synopsis
- Delayed fracture healing and nonunion affect 5-10% of fractures, posing challenges for doctors.
- Therapies to improve healing fall into two main categories: physical stimulation methods (like electrical stimulation and shock wave therapy) and biological therapies (divided into local and systemic methods).
- The article reviews the effectiveness and applications of these therapies in promoting better fracture healing outcomes.
Article Abstract
Delayed fracture healing and nonunion occurs in up to 5-10% of all fractures, and can present a challenging clinical scenario for the treating physician. Methods for the enhancement of skeletal repair may benefit patients that are at risk of, or have experienced, delayed healing or nonunion. These methods can be categorized into either physical stimulation therapies or biological therapies. Physical stimulation therapies include electrical stimulation, low-intensity pulsed ultrasonography, or extracorporeal shock wave therapy. Biological therapies can be further classified into local or systemic therapy based on the method of delivery. Local methods include autologous bone marrow, autologous bone graft, fibroblast growth factor-2, platelet-rich plasma, platelet-derived growth factor, and bone morphogenetic proteins. Systemic therapies include parathyroid hormone and bisphosphonates. This article reviews the current applications and supporting evidence for the use of these therapies in the enhancement of fracture healing.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119705 | PMC |
| http://dx.doi.org/10.11138/ccmbm/2016.13.2.101 | DOI Listing |
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