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From the Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, der Technischen Universität München, Ismaningerstr 22, 81675 Munich, Germany (D.M., A.A.F., S.R., F.K.K., F.P., E.J.R., P.B.N.); Department of Interventional Radiology and Cardio-vascular and Thoracic Diagnostic Imaging, Louis Pradel University Hospital, Bron, France (D.B.N., L.B., P.D.); Innovative Technologies, Research Laboratories, Philips GmbH, Hamburg, Germany (E.R., M.B., H.D., B.B., A.T., R.P.); Global Advanced Technologies, CT, Philips Healthcare, Haifa, Israel (I.B., M.R.); CT Clinical Science, Philips, Suresnes, France (P.C.); and Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München, Garching, Germany (J.H., F.P., P.B.N.).
Published: June 2017
AI Article Synopsis
Article Abstract
Purpose To investigate the feasibility of using spectral photon-counting computed tomography (CT) to differentiate between gadolinium-based and nonionic iodine-based contrast material in a colon phantom by using the characteristic k edge of gadolinium. Materials and Methods A custom-made colon phantom was filled with nonionic iodine-based contrast material, and a gadolinium-filled capsule representing a contrast material-enhanced polyp was positioned on the colon wall. The colon phantom was scanned with a preclinical spectral photon-counting CT system to obtain spectral and conventional data. By fully using the multibin spectral information, material decomposition was performed to generate iodine and gadolinium maps. Quantitative measurements were performed within the lumen and polyp to quantitatively determine the absolute content of iodine and gadolinium. Results In a conventional CT section, absorption values of both contrast agents were similar at approximately 110 HU. Contrast material maps clearly differentiated the distributions, with gadolinium solely in the polyp and iodine in the lumen of the colon. Quantitative measurements of contrast material concentrations in the colon and polyp matched well with those of actual prepared mixtures. Conclusion Dual-contrast spectral photon-counting CT colonography with iodine-filled lumen and gadolinium-tagged polyps may enable ready differentiation between polyps and tagged fecal material. RSNA, 2016.
