Background: There is no consensus about the time instant relative to the J point where ST deviation has to be measured for detection of acute ischemia in the ECG.
Methods: We analyzed 53 ECGs, recorded preceding emergency catheterization of acute coronary syndrome patients with a completely occluded culprit artery (cases), and 88 control ECGs recorded in the cardiology outpatient clinic. ECG-amplitude measurements were made every 10 ms, between 20 ms before till 80 ms after the J point. STEMI-detection algorithms varied from the traditional STEMI criterion (elevations in at least two adjacent ECG leads), via the STEMI equivalent criterion (depressions in V2 and V3), to the most liberal STEMI-detection algorithm in which elevations as well as depressions in two adjacent leads were considered as signs of ischemia.
Results: Diagnostic accuracy was highest (93.6%) for the most liberal STEMI-detection algorithm at 10 ms after the J point; sensitivity was 94.3% and specificity was 93.2%.
Conclusion: The results of our study suggest that STEMI detection close to the J point is optimal.
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http://dx.doi.org/10.1016/j.jelectrocard.2016.10.012 | DOI Listing |
Animal Model Exp Med
January 2025
Department of Pharmacology, Shantou University Medical College, Shantou, Guangdong, China.
Background: To investigate the toxicity of N-n-butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes.
Methods: The acute median lethal dose (LD) of F2 was determined using the Bliss method following intravenous administration in mice. Routine surface electrocardiograms (ECGs) and arterial blood pressures (aBPs) were recorded under general anesthesia in untreated and pharmacologically vagotomized mice injected with F2.
Entropy (Basel)
December 2024
Grupo de Sistema Cardiovascular, Instituto de Ingeniería Biomédica (IIBM), Facultad de Ingeniería, Universidad de Buenos Aires, Buenos Aires C1063, Argentina.
Myocardial ischaemia is a decompensation of the oxygen supply and demand ratio, often caused by coronary atherosclerosis. During the initial stage of ischaemia, the electrical activity of the heart is disrupted, increasing the risk of malignant arrhythmias. The aim of this study is to understand the differential behaviour of the ECG during occlusion of both the left anterior descending (LAD) and right anterior coronary artery (RCA), respectively, using spatio-temporal quantifiers from information theory.
View Article and Find Full Text PDFColomb Med (Cali)
January 2025
Karabuk University Faculty of Medicine, Department of Cardiology, Karabuk, Turkey Karabük University Karabuk University Faculty of Medicine Department of Cardiology Karabuk Turkey.
Background: The association of fragmented QRS (fQRS) with many cardiac pathologies such as cardiac fibrosis has been described previously. Paraaortic adipose tissue (PAT) is thought to be associated with many cardiac diseases and there is only one publication on its echocardiographic evaluation.
Aims: To describe the possible relationship between fQRS and PAT.
BMC Res Notes
January 2025
Department of Palliative Nursing, Tohoku University Graduate School of Medicine, 2- 1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.
Objective: Pain is subjective, and self-reporting pain might be challenging. Studies conducted to detect pain using biological signals and real-time self-reports pain are limited. We evaluated the feasibility of collecting pain data on healthy females' menstrual pain and conducted preliminary analysis.
View Article and Find Full Text PDFBMC Pregnancy Childbirth
January 2025
Department of Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Background: Lack of motivation and behavioral abnormalities are the hallmarks of postpartum depression (PPD). Severe uterine contractions during labor are pain triggers for psychiatric disorders, including PPD in women during the puerperium. Creating biomarkers to monitor PPD may help in its early detection and treatment.
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