AI Article Synopsis
- * In a study, pregnant rats exposed to low doses of alpha-cypermethrin showed increased body weight, elevated plasma glucose and lipid levels, and altered enzyme activities in both mothers and their offspring.
- * The exposure caused oxidative stress and disrupted the balance of antioxidants, affecting metabolic health in both the mother and the developing fetus, indicating that caution is needed when using this insecticide during pregnancy.
Article Abstract
Pyrethroid insecticides are extensively used in agriculture and in household activities. During pregnancy, they might affect maternal metabolic status and there after fetal development. In this work, we studied metabolic and redox effects of low dose alpha-cypermethrin exposure in pregnant rats and their offspring. The diet containing alpha cypermethrin at 0.02mg/kg/day was consumed during the entire gestation. Plasma biochemical parameters as well as liver lipid and oxidative stress markers were determined. Our results showed that alpha-cypermethrin induced an increase in body weight and in plasma glucose and lipid levels, as well as in plasma aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase activities in pregnant rats and their newborns. Pregnant rats showed cellular oxidative stress and altered oxidant-antioxidant status when treated by the insecticide and these disturbances were also seen in their newborns. In conclusion, low dose alpha-cypermethrin exposure induced several metabolic and redox alterations leading to maternal physiological impairments and to fetal metabolic changes. Alpha-cypermethrin should be used with caution especially during pregnancy.
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| http://dx.doi.org/10.1016/j.pestbp.2016.04.007 | DOI Listing |
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