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Prediction the functional impacts of highly deleterious non-synonymous variants of gene.
Mol Biol Res Commun
January 2025
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- TSGA10 is a protein involved in spermatogenesis and associated with various cancers, where mutations can lead to infertility and abnormal expression in tumors.
- Research identifies the impact of specific non-synonymous SNPs (nsSNPs) on TSGA10's structure and function using multiple predictive in-silico tools before conducting expensive lab experiments.
- The study highlights 15 significantly damaging amino acid changes, particularly in regions linked to interactions with other proteins, suggesting these mutations can greatly affect TSGA10's role in infertility and cancer research.
Impact of Changes in Criminal-Legal Practices During the COVID-19 Pandemic on the HIV Risk Behaviors of Women Who Use Drugs: Protocol for a Multimethods Qualitative Study.
JMIR Res Protoc
December 2024
Department of Social Work, Southern Connecticut State University, New Haven, CT, United States.
Background: HIV risk behavior in women who use drugs is related to myriad psychosocial issues, including incarceration. The experience of incarceration elevates women's HIV risk by disrupting social networks, housing, employment, and access to health care. During the COVID-19 pandemic, changes in criminal-legal practices resulted in decreased incarceration, especially among women.
View Article and Find Full Text PDFPHARMACOKINETICS OF METRONIDAZOLE IN GREEN (), LOGGERHEAD (), AND KEMP'S RIDLEY () SEA TURTLES AFTER SINGLE ORAL AND INTRAVENOUS DOSES.
J Zoo Wildl Med
December 2024
Florida Atlantic University, Harbor Branch Oceanographic Institute, Fort Pierce, FL 34936, USA.
Currently there are few antibacterial dosage regimens established to be safe and effective for sea turtles. Pharmacokinetic evaluation of antibiotics is an essential step in establishing accurate dosage guidelines for a particular species. Metronidazole is an antibiotic that is effective against anaerobic bacteria and some protozoa.
View Article and Find Full Text PDFHow can family members of patients in the intensive care unit be supported? A systematic review of qualitative reviews, meta-synthesis, and novel recommendations for nursing care.
Int J Nurs Stud Adv
December 2024
Faculty of Nursing and Midwifery, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Background: Families are an important part of the intensive care unit (ICU) team. Being a family member in the ICU can be distressing due to interacting factors, such as the critical condition of the patient, the responsibility of acting as the patient's advocate, and partaking in decision-making related to treatment. Nurses need to be aware of the family's well-being throughout the patient's ICU stay.
View Article and Find Full Text PDFAnticipating and suspending: the chronopolitics of cryopreservation.
Biosocieties
July 2024
Institute of Sociology, Goethe University Frankfurt am Main, Theodor-W.-Adorno-Platz 6, 60323 Frankfurt am Main, Germany.
The article brings together two disparate and so far largely disconnected bodies of research: the critical analysis of cryopreservation technologies and the debate on modes of anticipation. It starts with a short review of the state of the research on the concept of cryopolitics. In the next part I will suggest two revisions.
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