Time-lapse microscopy patent upheld in Europe: response to Pearce.

Reprod Biomed Online

Bioethics Institute Ghent, Ghent University, Belgium.

Published: February 2017

In this piece, we comment on the article by Pearce earlier in this journal. As Pearce correctly points out, what is fundamentally at issue in ESHRE et al's opposition to Stanford University's European patent on time-lapse microscopy is whether an exclusion from patentability, here of methods of medical diagnosis, should be interpreted narrowly or not. In the present case, the dominant piece of case law from the European Patent Office (EPO) gives a narrow interpretation of what a method of diagnosis must be in order not to be patentable. In their submissions to the EPO, ESHRE et al. have argued that this narrow interpretation is unfounded and incorrect.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rbmo.2016.10.011DOI Listing

Publication Analysis

Top Keywords

time-lapse microscopy
8
european patent
8
narrow interpretation
8
microscopy patent
4
patent upheld
4
upheld europe
4
europe response
4
response pearce
4
pearce piece
4
piece comment
4

Similar Publications

Constitutive mitochondrial dynamics ensure quality control and metabolic fitness of cells, and their dysregulation has been implicated in various human diseases. The large GTPase Dynamin-related protein 1 (Drp1) is intimately involved in mediating constitutive mitochondrial fission and has been implicated in mitochondrial cell death pathways. During ferroptosis, a recently identified type of regulated necrosis driven by excessive lipid peroxidation, mitochondrial fragmentation has been observed.

View Article and Find Full Text PDF

Observing quantum mechanical characteristics in biological processes is a surprising and important discovery. One example, which is gaining more experimental evidence and practical applications, is the effect of weak magnetic fields with extremely low frequencies on cells, especially cancerous ones. In this study, we use a mathematical model of ROS dynamics in cancer cells to show how ROS oscillatory patterns can act as a resonator to amplify the small effects of the magnetic fields on the radical pair dynamics in mitochondrial Complex III.

View Article and Find Full Text PDF

Time-lapse analysis of embryos classified as euploid, mosaic, and aneuploid after embryonic trophectoderm biopsy.

J Assist Reprod Genet

January 2025

Reproductive Medicine Department, Villa Mafalda, Via Monte Delle Gioie 5, 00199, Rome, Italy.

Purpose: Analyze morphokinetic, morphology, and KIDscore™Day5 in different PGT-A classes, focusing on putative mosaicism level and type.

Methods: The single-center retrospective study analyzed 832 embryoscope-cultured blastocysts from cycles with at least one putative mosaic, conducted from 2020 to 2022. A P-value < 0.

View Article and Find Full Text PDF

Polarized pectin accumulation regulates differential hypocotyl elongation at the dark-to-light transition.

Curr Biol

January 2025

Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences in Weifang, Weifang 261000, Shandong, China. Electronic address:

As one of the most influential environmental factors, light fundamentally shapes plant physiology and growth traits. The hypocotyl is critical for the morphological establishment of the seedling, and its length displays remarkable plasticity upon perception of changes in the light conditions. Although remodeling of the primary cell walls is well-documented to play an important role in hypocotyl growth, how the hypocotyl elongation rate is swiftly repressed at the dark-to-light transition remains elusive.

View Article and Find Full Text PDF

Live-cell microscopy routinely provides massive amounts of time-lapse images of complex cellular systems under various physiological or therapeutic conditions. However, this wealth of data remains difficult to interpret in terms of causal effects. Here, we describe CausalXtract, a flexible computational pipeline that discovers causal and possibly time-lagged effects from morphodynamic features and cell-cell interactions in live-cell imaging data.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!