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Anti-aging and tyrosinase inhibition effects of Cassia fistula flower butanolic extract. | LitMetric

Anti-aging and tyrosinase inhibition effects of Cassia fistula flower butanolic extract.

BMC Complement Altern Med

Department of Obstetrics & Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.

Published: December 2016

AI Article Synopsis

Article Abstract

Background: Natural products made from plant sources have been used in a variety of cosmetic applications as a source of nutrition and as a whitening agent. The flowers of Cassia fistula L, family Fabaceae, have been used as a traditional medicine for skin diseases and wound healing and have been reported to possess anti-oxidant properties. The anti-aging effect of C. fistula flower extract on human skin fibroblast was investigated.

Methods: The butanolic extraction of C. fistula flowers was completed and the active compounds were classified. The cytotoxicity of fibroblasts was evaluated by SRB assay for the purposes of selecting non-toxic doses for further experiments. The collagen and hyaluronic acid (HA) synthesis was then measured using the collagen kit and ELISA, respectively. Moreover, the enzyme activity, including collagenase, matrixmelloproteinase-2 (MMP-2) and tyrosinase, were also evaluated.

Results: It was found that the flower extract did not affect skin fibroblast cell growth (IC > 200 μg/mL). The results did show that the flower extract significantly increased collagen and HA synthesis in a dose dependent manner. The flower extract (50-200 μg/mL) also significantly inhibited collagenase and MMP-2 activity. Furthermore, this flower extract could inhibit the tyrosinase activity that causes hyperpigmentation, which induces skin aging.

Conclusions: The C. fistula flower extract displayed a preventive effect when used for anti-aging purposes in human skin fibroblasts and may be an appropriate choice for cosmetic products that aim to provide whitening effects, and which are designated as anti-aging facial skin care products.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135822PMC
http://dx.doi.org/10.1186/s12906-016-1484-3DOI Listing

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