Background: Increasing evidence continues to demonstrate a survival advantage for bilateral internal mammary artery (BIMA) over single internal mammary artery (SIMA) for coronary artery bypass grafting (CABG). However, there are still doubts about which surgical strategy is the best one to use with BIMA grafting. This study aims to compare immediate and mid-term outcomes with BIMA CABG, using different surgical techniques, through transit-time flow measurement (TTFM) and clinical follow-up.
Methods: In this retrospective study, there were included 170 consecutive patients who underwent CABG between February 2011 and June 2014 in one single center. Patients were 95.9% men with a mean age of 58.8±8.6 years (range 35-78). The global cohort was then divided in subgroups: the in situ / composite "Y" graft subgroups and the off-pump / on-pump subgroups. TTFM assessment was used in 100% of the grafts. Mid-term follow-up was complete in 100% of patients.
Results: In 57.6% of patients, BIMA were used in situ: right internal thoracic artery (RIMA) to left anterior descending artery (LAD) and left internal thoracic artery (LIMA) to circumflex (Cx) branches and in 42.4% of patients, RIMA was anastomosed to LIMA in a "Y" shape: LIMA to LAD and RIMA to Cx branches. RIMA/LIMA-LAD and RIMA/LIMA-OM grafts mean flow and mean pulsatility index were 35.4 ml/min and 2.6, and 29.6ml/min and 2.6, respectively. There were no differences on in situ or "Y" shape grafts regarding pulsatility index. There were also no differences regarding pulsatility index and morbidity between surgeries performed off or on-pump. In a mean follow-up time of 18.8 months, 97.6% of patients had complete angina relief and there was no mortality.
Conclusions: CABG surgery with BIMA grafting can be safely performed, even in patients with multiple risk factors, without compromising grafts quality, regardless the surgical technique.
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Asian Pac J Cancer Prev
January 2025
Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Objective: Programmed Death-Ligand 1 (PD-L1) and Cytotoxic T Lymphocyte -Associated Antigen-4 (CTLA-4) are presently considered as prognostic markers and therapeutic targets in numerous human malignancies. The goal of this study was to determine whether PD-L1 and CTLA-4 might be used to predict patients' survival in Triple Negative Breast Cancer (TNBC).
Methods: This retrospective cohort study analyzed 100 primary TNBC cases that had surgical resection at the Oncology Center of Mansoura University (OCMU), Faculty of Medicine, Egypt.
Asian Pac J Cancer Prev
January 2025
Research Center for Vaccine and Drugs, The National Research and Innovation Agency (BRIN), South Tangerang 15310, Indonesia.
Objective: The progress made in cancer immunology has led to the development of innovative therapeutic strategies. However, despite these advances, the superficial characteristics of immune cells have been frequently overlooked: This oversight may be attributed to a limited understanding of the intricate relationships between immune cells and their microenvironment. This study seeks to address this limitation by comprehensively examining cell size and granularity in breast cancer (BC) patients and healthy donors (HD).
View Article and Find Full Text PDFAsian Pac J Cancer Prev
January 2025
Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital Yogyakarta, Indonesia.
Background: Cancer cachexia in breast cancer (BC) patients is not commonly reported, particularly in Indonesia. This study assessed the prevalence of cachexia in local patients with BC receiving chemotherapy, and the associated factors.
Methods: This cross-sectional study included 160 BC patients who started chemotherapy between July 2018 and June 2022.
Asian Pac J Cancer Prev
January 2025
Department of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran.
Background: LIN28, a highly conserved RNA-binding protein, regulate a wide variety of post-transcriptional cellular processes. The current study aimed to identify genetic variants of five single nucleotide polymorphisms (SNPs) in the LIN28B gene (rs221634, rs22163, rs314276, rs9404590, and rs12194974) and their association with Breast cancer.
Method: 220 patients and 230 controls were genotyped by the RFLP assay for Lin28B gene variants.
Cureus
January 2025
Internal Medicine, Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria, Lisbon, PRT.
The bone tissue is a specialised connective tissue composed of several components that undergo constant remodelling. The balance between bone deposition and resorption is essential for maintaining a healthy bone structure. In case of a disruption in this remodelling process, which can lead to an imbalance between bone deposition and resorption, an increase in the opacity of a vertebral body may be observed in imaging studies, resulting in what is known as the "ivory vertebra sign".
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