In this issue of Molecular Cell, Ritt et al. (2016) describe a stress-induced checkpoint that effectively suppresses RAS-MAPK signaling. This pathway, activated by agents such as Rigosertib that induce mitotic and oxidative stress, results in JNK-mediated inhibition of RAS-MAPK pathway components SOS and RAF.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.molcel.2016.11.024 | DOI Listing |
Publication Analysis
Top Keywords
ras/mapk axis
4
axis stressed
4
stressed issue
4
issue molecular
4
molecular cell
4
cell ritt
4
ritt et al
4
et al 2016
4
2016 describe
4
describe stress-induced
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!