Objective The aim of this study was to describe the application of latent class growth analysis (LCGA) to identify different working life trajectories (WLT) using employed working time by year as a repeated measure. Methods Trajectories are estimated using LCGA, which considers all individuals within a trajectory to be homogeneous. The methodology was applied to a subsample of the Spanish WORKing life Social Security (WORKss) cohort, limited to persons born 1956-1965 (N=247 475). The number of days worked per year is used as a repeated measure across 32 time points (1981-2013). Results According to the model-fit results and further guided by expert knowledge, a four WTL model was selected as the optimal approach: WLT1 or "high labor force participation" (N=99 591; 40.2%); WLT2 or "decreased labor force participation" (N= 22 846; 9.2%); WLT3 or "increased labor force participation" (N=59 213; 23.9%); and WLT4 or "low labor force participation" (N=65 827; 26.6%). WLT1 consisted mainly of men with more years of work experience (>19 years) while WLT4 was mainly composed by women with <9 years. The other two trajectories had opposite trends and no sex differences. The occupational category variable had little influence in the trajectories. Conclusions Longitudinal data that are regularly collected by administrative systems can benefit from LCGA approaches to identify different trajectory patterns that may be associated with an outcome of interest. In occupational epidemiology, this study represents a step forward by using this modeling approach to identify different WLT.
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AAPS J
January 2025
Certara UK Limited, Level 2, Acero, 1 Concourse Way, Sheffield, S1 2BJ, UK.
Bile salts are biosurfactants released into the intestinal lumen which play an important role in the solubilisation of fats and certain drugs. Their concentrations vary along the gastrointestinal tract (GIT). This is significant for implementation in physiologically based pharmacokinetic (PBPK) modelling to mechanistically capture drug absorption.
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January 2025
Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Purpose: The expression of the respiratory events in OSA is influenced by different mechanisms. In particular, REM sleep can highly increase the occurrence of events in a subset of OSA patients, a condition dubbed REM-OSA (often defined as an AHI 2 times higher in REM than NREM sleep). However, a proper characterization of REM-OSA and its pathological sequelae is still inadequate, partly because of limitations in the current definitions.
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March 2025
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, PR China. Electronic address:
Cellulose nanocrystals (CNCs) are powerful biosourced nanomaterials for the construction of chiral photonic films. While various techniques have been used to enrich the optical properties of such systems, surface roughness engineering has yet to be exploited to significantly modify their optical properties. In this work, by using vacuum filtration-assisted self-assembly, CNCs are densely packed into films with high optical transparency.
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ARKRAY Healthcare Pvt. Ltd., Plot No. 336, 338, 340, Rd Number 3, GIDC, Sachin, 394230 Surat, Gujarat, India.
A lateral flow immunoassay (LFIA) employing palladium nanoparticles (PdNPs) labelled with antibodies has been innovatively designed for the precise detection of Plasmodium falciparum pLDH and HRPII antigen. This study focuses on development of LFIA based on PdNPs detection system to substantially enhance the visual detectability (vLOD), achieving an impressive 12 parasites/microliter (p/µl) vLOD in comparison with conventional system represented 50 p/µl vLOD. The research introduces a novel amplification system that not only heightens the sensitivity of LFIA but also maintains intense coloration.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address:
Myricetin has a significant role in pharmacology, specifically in traditional Chinese medicine. The most intriguing pharmacological action of myricetin consists of its multi-pathway anticancer effects. Therefore, rapid and selective isolation of myricetin from garlic and apple juices has notable pharmacological benefits.
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