This is a case report of rare iridal involvement in intraocular lymphoma confirmed by the full range of diagnostic measures, including ultrasound biomicroscopy, optical coherence tomography of the anterior segment of the eye, iridectomy with biopsy and further cytological and histopathological examination of the obtained material.
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[Iridal lymphoma (clinical case)].
Vestn Oftalmol
March 2017
Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062.
This is a case report of rare iridal involvement in intraocular lymphoma confirmed by the full range of diagnostic measures, including ultrasound biomicroscopy, optical coherence tomography of the anterior segment of the eye, iridectomy with biopsy and further cytological and histopathological examination of the obtained material.
View Article and Find Full Text PDFOsteopontin-integrin interaction as a novel molecular target for antibody-mediated immunotherapy in adult T-cell leukemia.
Retrovirology
November 2015
Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-0815, Japan.
Background: Adult T-cell leukemia (ATL) is a CD4(+) T-cell neoplasm with a poor prognosis. A previous study has shown that there is a strong correlation between the secreted matricellular protein osteopontin (OPN) level and disease severity in ATL patients. Here, we investigated the role of OPN in ATL pathogenesis and the possible application of anti-OPN monoclonal antibody (mAb) for ATL immunotherapy in NOD/Shi-scid,IL-2Rg (null) (NOG) mice.
View Article and Find Full Text PDFUveodermatologic lymphoma in two young related Portuguese water dogs.
Vet Ophthalmol
September 2012
Servei d'Oftalmologia Veterinària, Fundació Hospital Clínic Veterinari, Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Campus de la UAB, Edifici V. 08193. Bellaterra, Barcelona, Spain.
Purpose: Canine lymphoma (CL) is one of the most common forms of spontaneous canine neoplasia. Improved understanding of the genetic and environmental factors associated with CL may provide benefits for the study of non-Hodgkin's and Hodgkin's lymphoma in humans. Uveodermatologic lymphoma is reported in a single household of Portuguese water dog, and the etiology is discussed.
View Article and Find Full Text PDFUnderstanding intraocular lymphomas.
Clin Exp Ophthalmol
August 2008
Department of Cellular and Molecular Pathology, University of Liverpool, Liverpool, UK.
The purpose of this review is to describe the clinical features, pathology and molecular biology of intraocular lymphomas, which represent a heterogenous group of malignant neoplasms; to propose an anatomical classification of these tumours according to whether they occur in the retina or uvea; and to overview laboratory investigations and highlight factors required for successful biopsy. Recent findings show that retinal lymphomas are high-grade (i.e.
View Article and Find Full Text PDFClassification of feline intraocular neoplasms based on morphology, histochemical staining, and immunohistochemical labeling.
Vet Ophthalmol
December 2006
Department of Small Animal Clinical Sciences, Western Colleg of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
The objectives of this study were to evaluate morphologic, histochemical, and immunohistochemical characteristics of well-differentiated and anaplastic intraocular neoplasms of cats, and to develop a diagnostic algorithm for, and investigate the association of ruptured lenses with these neoplasms. Seventy-five feline globes with intraocular neoplasms were stained with hematoxylin and eosin and examined by light microscopy. Morphologic diagnoses included 33 intraocular sarcomas, 17 diffuse iris melanomas, 15 lymphosarcomas, three ciliary adenomas, one metastatic carcinoma, and six undifferentiated intraocular neoplasms.
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