The FDA has approved a multicenter, double-blind, Phase III, pivotal trial testing deep brain stimulation (DBS) in 280 people with very early stage Parkinson's disease (PD; IDE#G050016). In partnership with The Michael J. Fox Foundation for Parkinson's Research, we conducted a survey to investigate motivating factors, barriers, and gender differences among potentially eligible patients for participation in a trial testing DBS in early PD compared to standard medical treatment. The majority of survey respondents (72%) indicated they would consider learning more about participating. Early PD patients are therefore likely to consider enrolling in trials of invasive therapies that may slow symptom progression and help future patients.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.3233/JPD-161031 | DOI Listing |
Heliyon
January 2025
School of Music, College of Fine Arts, University of Tehran, Tehran, Iran.
Sleep stages classification one of the essential factors concerning sleep disorder diagnoses, which can contribute to many functional disease treatments or prevent the primary cognitive risks in daily activities. In this study, A novel method of mapping EEG signals to music is proposed to classify sleep stages. A total of 4.
View Article and Find Full Text PDFBrain Behav Immun Health
February 2025
Healthy Brain Ageing Program, Brain and Mind Centre, School of Psychology, Faculty of Science, University of Sydney, NSW, 2050, Australia.
Inflammation is becoming increasingly recognised as a core feature of dementia with evidence indicating that its role may vary and adapt across different stages of the neurodegenerative process. This study aimed to investigate whether the associations of high-sensitivity C-reactive protein (hs-CRP) with neuropsychological performance (verbal memory, executive function, processing speed) and cerebral white matter hyperintensities (WMHs) differed between older adults with subjective cognitive decline (SCD; = 179) and mild cognitive impairment (MCI; = 286). Fasting serum hs-CRP concentrations were grouped into low (<1.
View Article and Find Full Text PDFMath Biosci Eng
December 2024
Department of Electronics and Communication Engineering, Akshaya College of Engineering and Technology, Coimbatore, Tamil Nadu, India.
The hippocampus is a small, yet intricate seahorse-shaped tiny structure located deep within the brain's medial temporal lobe. It is a crucial component of the limbic system, which is responsible for regulating emotions, memory, and spatial navigation. This research focuses on automatic hippocampus segmentation from Magnetic Resonance (MR) images of a human head with high accuracy and fewer false positive and false negative rates.
View Article and Find Full Text PDFInt J Surg
December 2024
Department of Neurosurgery, Stanford University, Stanford, Palo Alto, California, USA.
Deep brain stimulation (DBS) has emerged as a crucial therapeutic strategy for various neurological and psychiatric disorders. Precise target localization is essential for optimizing therapeutic outcomes, necessitating advanced neuroimaging techniques. Normative atlases provide standardized references for accurate electrode placement, enhancing treatment customization and efficacy.
View Article and Find Full Text PDFFluids Barriers CNS
January 2025
Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.
Background: Cerebral autoregulation is a robust regulatory mechanism that stabilizes cerebral blood flow in response to reduced blood pressure, thereby preventing cerebral ischaemia. Scientists have long believed that cerebral autoregulation also stabilizes cerebral blood flow against increases in intracranial pressure, which is another component that determines cerebral perfusion pressure. However, this idea was inconsistent with the complex pathogenesis of normal pressure hydrocephalus, which includes components of chronic cerebral ischaemia due to mild increases in intracranial pressure.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!