Background: The presence of digestive fistula involves chronic inflammation and fibrosis. It has been reported that ω3-polyunsaturated fatty acids stimulate the resolution of inflammation.
Aim: Determine if the administration of oral ω3 reduces fistula output and the time required for fistula closure.
Methods: Forty-nine patients with postoperative fistula were randomly divided in two groups: 26 received conventional treatment and 23 received the conventional treatment supplemented with ω3 (540 mg eicosapentaenoic acid and 360 mg docosahexaenoic acid) for 35 days. Patients were monitored daily for fistula output and spontaneous closure. Additionally, serum pro-inflammatory cytokines and C-reactive protein were quantified in four patients with conventional and in seven patients with ω3 treatment.
Results: Patients with ω3 had significantly decreased fistula output from days 2 to 27, compared to control (p < 0.05). Spontaneous fistula closure was achieved in 15 patients (65%) in the ω3 group and in 14 (54%) in the control group. ω3-polyunsaturated fatty intake also decreased the serum concentrations of interleukin-6 and C-reactive protein (p < 0.05).
Conclusions: Our results suggest that ω3 supplementation to conventional medical treatment decreases fistula output and reduces inflammation (interleukin-6 and C-reactive protein), and these effects may increase the efficiency of conventional medical treatment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11605-016-3333-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Successful endovascular treatment of post-traumatic subclavian arteriovenous fistula.
J Surg Case Rep
December 2024
Department of Surgery, Hackensack Meridian Health Jersey Shore University Medical Center, 1945 Route 33, Neptune, NJ 07756, United States.
Subclavian arteriovenous fistulas (AVFs) are rare entities, mostly reported as a result of traumatic and iatrogenic injuries. In the literature, congenital subclavian AVFs are also presented. Diagnosis of traumatic AVF may present challenges given the variable clinical presentation, varying location, and difficulty to locate on imaging.
View Article and Find Full Text PDFHemodialysis Vascular Access: Core Curriculum 2025.
Am J Kidney Dis
December 2024
Department of Medicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham, Alabama.
The majority of patients with kidney failure requiring replacement therapy will need the support of hemodialysis during their journey with kidney failure. A reliable functioning vascular access is required to provide hemodialysis. This Core Curriculum reviews the major forms of vascular access (arteriovenous fistula, arteriovenous graft, and central venous catheter) as well as the planning, preparation, creation, use, and maintenance of vascular access, requiring a P-L-A-N (Patient ESKD Life-Plan first then Access Needs) for each patient.
View Article and Find Full Text PDFUse of parenteral nutrition in the management of enterocutaneous fistula.
Nutr Clin Pract
February 2025
Department of Surgery, Denver Health Medical Center, University of Colorado, Denver, Colorado, USA.
Nutrition plays an integral role in the management of patients with enterocutaneous fistula (ECF), but practice guidelines are often vague because of limited evidence. As a result, clinicians must rely on expert consensus and sound nutrition principles to guide practice. The initial phase of ECF management involves recognition (eg, fistula location and quantifying output) and stabilization (eg, source control and fluid and electrolyte balance).
View Article and Find Full Text PDFManagement of subarachnoid-pleural fistula following anterior transthoracic approach for the ossification of posterior longitudinal ligament in the thoracic spine.
J Neurol Surg A Cent Eur Neurosurg
November 2024
Spinal Disorders Center, Fujieda Heisei Memorial Hospital, Fujieda city, Japan.
Background: Subarachnoid-pleural fistula is an abnormal communication between the subarachnoid and pleural spaces that can arise from blunt or penetrating trauma or as a complication of spinal surgery via the transthoracic approach. Uncontrolled cerebrospinal fluid (CSF) leakage with a fistulous condition after transthoracic spinal surgery could be more problematic than that after spinal surgery via the conventional posterior approach because of the negative pressure in the pleural cavity.
Case Description: The authors reported subarachnoid-pleural fistula management using chest and lumbar spinal drainage in five patients with several troublesome complications, such as intracranial subdural hematoma or severe respiratory dysfunction.
Model of superior semicircular canal dehiscence: asymmetrical vestibular dysfunction induces reversible balance impairment.
Front Neurol
October 2024
Department of Head and Neck Surgery & Communication Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States.
Background: Superior semicircular canal dehiscence (SSCD) is a vestibular-cochlear disorder in humans in which a pathological third mobile window of the otic capsule creates changes to the flow of sound pressure energy through the perilymph/endolymph. The primary symptoms include sound-induced dizziness/vertigo, inner ear conductive hearing loss, autophony, headaches, and visual problems. We have developed an animal model of this human condition in the Mongolian Gerbil that uses surgically created SSCD to induce the condition.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!