Objectives: To investigate the therapeutic effect of gelatin microspheres containing different concentrations of calcitonin gene-related peptide (CGRP) or substance P on repairing bone defects in a rabbit osteoporosis model.
Results: Gelatin microspheres containing different concentrations of CGRP or substance P promoted osteogenesis after 3 months in a rabbit osteoporotic bone defective model. From micro-computed tomography imaging results, 10 nM CGRP was optimal for increasing the trabecular number and decreasing the trabecular bone separation degree; similar effects were observed with the microspheres containing 1 µM substance P. Histological analysis showed that the gelatin microspheres containing CGRP or substance P, regardless of the concentration, effectively promoted osteogenesis, and the highest effect was achieved in the groups containing 1 µM CGRP or 1 µM substance P.
Conclusions: Gelatin microspheres containing CGRP or substance P effectively promoted osteogenesis in a rabbit osteoporotic bone defect model dose-dependently, though their effects in repairing human alveolar ridge defects still need further investigation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10529-016-2263-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bioactive microspheres to enhance sonodynamic-embolization-metalloimmune therapy for orthotopic liver cancer.
Biomaterials
December 2024
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China. Electronic address:
The development of novel microspheres for the combination of sonodynamic therapy (SDT) with transarterial embolization (TAE) therapy to amplify their efficacy has received increasing attention. Herein, a novel strategy for encapsulating sonosensitizers (e.g.
View Article and Find Full Text PDF4D bioprinting of transformable living constructs with sustained local growth factor presentation for advanced tissue engineering applications.
Colloids Surf B Biointerfaces
December 2024
Cardiovascular Center, The First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address:
Traditional tissue engineering strategies focus on geometrically static tissue scaffolds, lacking the dynamic capability found in native tissues. The emerging field of 4D bioprinting offers a promising method to address this challenge. However, the requirement for consistent exogenous supplementation of growth factors (GFs) during tissue maturation poses a significant obstacle for in vivo application of 4D bioprinted constructs.
View Article and Find Full Text PDFPreparation of cellulose-based fluorescent aggregations with various morphologies and their microstructure-correlated fluorescence behavior.
Int J Biol Macromol
December 2024
School of Textile Science and Engineering, Xi'an Polytechnic University, Xi'an 710048, Shaanxi, China; Key Laboratory of Functional Textile Material and Product, Xi'an Polytechnic University, Ministry of Education, Xi'an 710048, Shaanxi, China. Electronic address:
Article Synopsis
- An efficient method was developed to create cellulose-based fluorescent materials with customizable shapes and sizes using cross-linking copolymerization and self-assembly techniques.
- Fluorescein isothiocyanate (FITC) was successfully encapsulated into these materials, resulting in various morphologies, including flower-like and tentacle-like designs, depending on the composition of cellulose and gelatin.
- The flower-like aggregates exhibited the highest fluorescence intensity due to their structure, which minimizes interactions that can reduce fluorescence, indicating potential uses in applications such as information storage and special fibers.
Local glycolysis-modulating hydrogel microspheres for a combined anti-tumor and anti-metastasis strategy through metabolic trapping strategy.
J Control Release
December 2024
Department of Biomaterials and Biomedical Technology, The Personalized Medicine Research Institute (PRECISION), University Medical Center Groningen (UMCG), University of Groningen, 9713 AV Groningen, the Netherlands; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland. Electronic address:
Anti-glycolysis is well-recognized for inhibition of tumor proliferation. However, tumor metabolic heterogeneity confers great challenges in the therapeutic efficacy of glycolysis inhibitors. Here, a metabolic trapping strategy was employed to avoid metabolism heterogeneity in tumors.
View Article and Find Full Text PDFInjectable hypoxia-preconditioned human exfoliated deciduous teeth stem cells encapsulated within GelMA-AMP microspheres for bone regeneration in periodontitis.
Colloids Surf B Biointerfaces
December 2024
Department of Stomatology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. Electronic address:
Periodontitis, an inflammatory and infectious disease resulting from dental plaque, affects tooth-supporting tissues and interconnects with various systemic conditions. Advancing periodontal tissue regeneration stands as pivotal in periodontitis treatment. Presently, odontogenic stem cells garner substantial interest for dental pulp functional tissue regeneration.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!