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Management of Anomalous Left Vertebral Artery During Open Total Arch Replacement.
Ann Thorac Surg Short Rep
December 2024
Division of Cardiac Surgery, Department of Surgery, Northwestern University Feinberg School Medicine, Chicago, Illinois.
Background: An anomalous left vertebral artery (aLVA) can complicate aortic arch surgery. We examined the safety of various aLVA revascularization strategies during open total arch replacement.
Methods: We retrospectively evaluated 92 patients undergoing total arch replacement from January 2018 to May 2023 and identified 11 patients with aLVA.
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Alzheimers Dement
December 2024
Center for Life Ethics, University of Bonn, Bonn, Germany.
Background: In recent years, research on risk estimation and early detection of Alzheimer's disease (AD) advanced swiftly. Studies are investigating the likelihood of developing Alzheimer's dementia (ADD), even during asymptomatic, preclinical, and prodromal stages of AD. Particular hope is pinned on blood-based biomarkers as these are less invasive than other methods such as lumbar puncture and Positron Emission Tomography (PET)-scan.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Central Clinical School, Monash University, Melbourne, VIC, Australia.
Background: Identifying biomarkers for primary tau pathologies like Progressive Supranuclear Palsy (PSP) is crucial for diagnosis and treatment development. The novel positron emission tomography (PET) radiotracer F-PI-2620 shows promise in detecting tau protein in PSP and this study investigates its correlation with clinical markers.
Methods: We conducted a cross-sectional analysis on 20 patients with clinically diagnosed probable PSP (Richardson's Syndrome), who underwent T1-weighted MRI, lumbar puncture, blood testing, and 0-60 min dynamic F-PI-2620 PET scanning.
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Alzheimers Dement
December 2024
Research Center of Neurology, Moscow, Russian Federation.
Background: The logopenic variant of primary progressive aphasia (lvPPA) is a disorder centered on language impairment. Alzheimer Disease (AD) is one of the most common underlying pathologies in lvPPA. The aim of our study was to estimate frequency of AD in this phenotype and to analyze clinical features of AD-lvPPA.
View Article and Find Full Text PDFBackground: With the emergence of disease-modifying therapies (DMTs) for early Alzheimer's disease (AD), evolution of healthcare infrastructure is needed to identify patients eligible for treatment with an AD DMT, and to adequately treat and monitor patients throughout. Our research aimed to assess current practices and available infrastructure, to identify bottlenecks, and to propose solutions to increase patient access to AD DMTs in the EU4+UK.
Methods: We searched publicly available information (to August 2023) to derive a foundational understanding of the current level of healthcare infrastructure in each country.
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