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The Role of TSLP and IL-1 β and Their Genetic Variants in the Pathogenesis of Single and Multiple Atopic Diseases in Children.
J Clin Med
January 2025
Department and Clinic of Paediatrics, Allergology and Cardiology, Wroclaw Medical University, ul. Chałubińskiego 2a, 50-368 Wrocław, Poland.
Allergic diseases commonly coexist, manifesting in a sequence described as the "allergic march". This study aimed to evaluate TSLP's and IL-1β's potential as biomarkers in both single and multi-pediatric atopic diseases like atopic eczema, food allergy, and anaphylaxis and analyze specific SNPs in the TSLP and IL-1β genes to determine their associations with their occurrence and severity. This analysis included 109 atopic children diagnosed with atopic dermatitis, food allergy, or anaphylaxis alongside a control group of 57 non-atopic children.
View Article and Find Full Text PDFMedical Digital Twin: A Review on Technical Principles and Clinical Applications.
J Clin Med
January 2025
Neuroradiology Unit, Ospedale del Mare ASL NA1 Centro, 80145 Naples, Italy.
The usage of digital twins (DTs) is growing across a wide range of businesses. The health sector is one area where DT use has recently increased. Ultimately, the concept of digital health twins holds the potential to enhance human existence by transforming disease prevention, health preservation, diagnosis, treatment, and management.
View Article and Find Full Text PDFAre Trace Elements Provided for Children on Long-Term Parenteral Nutrition Adequate to Meet Their Needs?
Life (Basel)
December 2024
The Children's Memorial Health Institute, Department of Pediatrics, Nutrition and Metabolic Diseases, 04-730 Warsaw, Poland.
: We conducted a cross-sectional study to investigate whether children receiving long-term parenteral nutrition (LPN) are at risk of imbalances in selected trace elements. : Serum levels of manganese, zinc, copper, selenium, and iodine were measured in 83 children on LPN and compared with 121 healthy controls. Children with signs of infection or elevated C-reactive protein levels were excluded.
View Article and Find Full Text PDFPrenatally Diagnosed Cardiac Tumors and Tuberous Sclerosis Complex: A Single-Center Experience.
Children (Basel)
January 2025
Department of Pediatrics, Division of Neonatology and Neonatal Intensive Medicine, University Hospital Centre Zagreb, 10000 Zagreb, Croatia.
Background/objectives: Cardiac rhabdomyoma (CR), the most frequently occurring fetal cardiac tumor, is often an early marker of tuberous sclerosis complex (TSC). This study evaluates outcomes of fetuses with prenatally diagnosed cardiac tumors managed at a single tertiary center.
Methods: Medical records of fetuses diagnosed with cardiac tumors between 2009 and 2024 were retrospectively reviewed.
Cardiovascular Disease Screening in Primary School Children.
Children (Basel)
December 2024
School of Medicine, University of Crete, 71 003 Heraklion, Crete, Greece.
Background: Screening for cardiovascular disease (CVD) and its associated risk factors in childhood facilitates early detection and timely preventive interventions. However, limited data are available regarding screening tools and their diagnostic yield when applied in unselected pediatric populations.
Aims: To evaluate the performance of a CVD screening program, based on history, 12-lead ECG and phonocardiography, applied in primary school children.
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