AI Article Synopsis
- Optogenetic effectors enable researchers to study the function of natural proteins by controlling them with light.
- There are primarily two methods for creating these effectors: caging strategies that modify protein shape with light and relocalization strategies that utilize light to control interactions between proteins.
- Current efforts are aimed at enhancing general techniques for light-based control of proteins and improving methods for screening and selecting light-sensitive proteins.
Article Abstract
Photo-controlled or 'optogenetic' effectors interfacing with endogenous protein machinery allow the roles of endogenous proteins to be probed. There are two main approaches being used to develop optogenetic effectors: (i) caging strategies using photo-controlled conformational changes, and (ii) protein relocalization strategies using photo-controlled protein-protein interactions. Numerous specific examples of these approaches have been reported and efforts to develop general methods for photo-control of endogenous proteins are a current focus. The development of improved screening and selection methods for photo-switchable proteins would advance the field.
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| http://dx.doi.org/10.1016/j.sbi.2016.11.014 | DOI Listing |
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